舒马曲坦对大鼠心脏缺血状态的影响。
The Effect of Sumatriptan in Ischemic Conditions in the Rat Heart.
作者信息
Altunkaynak-Çamca Hande Özge, Tecder-Ünal Müge, Tuncer Meral
机构信息
Başkent University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey.
出版信息
Turk J Pharm Sci. 2018 Dec;15(3):328-332. doi: 10.4274/tjps.03371. Epub 2018 Nov 20.
OBJECTIVES
The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection.
MATERIALS AND METHODS
The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC. The mean arterial blood pressure and heart rate were recorded to calculate PRP. Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters.
RESULTS
The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p<0.05). The incidence of VT in the IPC, SUM-IR, and SUM-IPC groups was significantly lower than in the IR group (p<0.05). VF was only observed in the IR group.
CONCLUSION
SUM protects the heart against IR injury but is not as protective as IPC alone. Although SUM diminishes IPC-induced protection against VT, the preventive effect of SUM against VF may be predictive for cardioprotection in ischemic conditions.
目的
本研究旨在探讨SUM对大鼠心脏缺血再灌注损伤的影响及其对缺血预处理诱导的保护作用的影响。
材料与方法
将大鼠随机分为四组：缺血再灌注组（IR）、SUM-缺血再灌注组、缺血预处理组（IPC）和SUM-缺血预处理组。记录平均动脉血压和心率以计算压力速率乘积（PRP）。记录标准肢体导联II心电图以评估心律失常参数。
结果
再灌注开始时，SUM-缺血预处理组的PRP值显著低于SUM-缺血再灌注组（p<0.05）。缺血预处理组、SUM-缺血再灌注组和SUM-缺血预处理组的室性心动过速（VT）发生率显著低于缺血再灌注组（p<0.05）。仅在缺血再灌注组观察到心室颤动（VF）。
结论
SUM可保护心脏免受缺血再灌注损伤，但保护作用不如单独的缺血预处理。虽然SUM减弱了缺血预处理诱导的对VT的保护作用，但SUM对VF的预防作用可能对缺血条件下的心脏保护具有预测性。
Zotero 插件