Venturelli Marta, Toss Angela, Cortesi Laura, Gambini Anna, Andreotti Alessia, Cascinu Stefano, Tazzioli Giovanni, Moscetti Luca
Department of Oncology and Hematology, University Hospital of Modena, I-41124 Modena, Italy.
Oncologic Breast Surgery Unit, University Hospital of Modena, I-41124 Modena, Italy.
Mol Clin Oncol. 2020 Jul;13(1):33-37. doi: 10.3892/mco.2020.2038. Epub 2020 Apr 30.
Myofibroblastoma of the breast is a rare benign stromal tumor that occurs in both sexes with a higher prevalence in male breast of older populations. Furthermore, myofibroblastoma can arise in extra mammary sites, along the milk-line. A variety of morphological variants in addition to the classic type have been identified. The differential diagnosis includes both benign and malignant entities that, through the use of clinical and radiological imaging, is difficult to characterize. Histopathological examination and immunohistochemistry are fundamental in the establishment of appropriate management of the disease and avoidance of overtreatment. The present study focuses on two cases of male mammary myofibroblastoma, with a short literature review.
乳腺肌纤维母细胞瘤是一种罕见的良性间质肿瘤,男女均可发生,在老年男性乳腺中更为常见。此外,肌纤维母细胞瘤可发生于乳腺外沿乳线的部位。除经典类型外,还发现了多种形态学变异型。鉴别诊断包括良性和恶性病变,通过临床和放射影像学检查难以明确其特征。组织病理学检查和免疫组化对于制定合适的疾病治疗方案及避免过度治疗至关重要。本研究重点关注两例男性乳腺肌纤维母细胞瘤病例,并进行简要文献回顾。