基于斑马鱼的抗转移药物筛选模型。

Shonai Regional Industry Promotion Center, Tsuruoka, Yamagata, 997-0052, Japan.

Tsuruoka Metabolomics Laboratory, National Cancer Center, Mizukami 246-2, Kakuganji, Tsuruoka, Yamagata 975-0052, Japan.

Molecules. 2020 May 21;25(10):2407. doi: 10.3390/molecules25102407.

Metastasis, a leading contributor to the morbidity of cancer patients, occurs through a multi-step process: invasion, intravasation, extravasation, colonization, and metastatic tumor formation. Each process is not only promoted by cancer cells themselves but is also affected by their microenvironment. Given this complexity, drug discovery for anti-metastatic drugs must consider the interaction between cancer cells and their microenvironments. The zebrafish is a suitable vertebrate animal model for in vivo high-throughput screening studies with physiological relevance to humans. This review covers the zebrafish model used to identify anti-metastatic drugs.

转移是导致癌症患者发病和死亡的主要原因，它是一个多步骤的过程：侵袭、入血、血管外渗、定植和转移瘤形成。每个过程不仅受到癌细胞本身的促进，还受到其微环境的影响。鉴于这种复杂性，抗转移药物的药物发现必须考虑癌细胞与其微环境之间的相互作用。斑马鱼是一种合适的脊椎动物动物模型，可用于进行具有与人类生理相关性的体内高通量筛选研究。本文综述了用于鉴定抗转移药物的斑马鱼模型。