Equipe d'Accueil (EA 7460) Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Faculté des Sciences de Santé, Université de Bourgogne-Franche Comté, 7 Bd Jeanne d'Arc, 21000 Dijon, France.
Centre Interface Applications Médicales (CIAM), Université Mohammed VI Polytechnique, Ben-Guerir 43 150, Morocco.
Molecules. 2020 May 22;25(10):2417. doi: 10.3390/molecules25102417.
The transfer of metabolites through the mitochondrial membranes is a vital process that is highly controlled and regulated by the inner membrane. A variety of metabolites, nucleotides, and cofactors are transported across the inner mitochondrial membrane (IMM) by a superfamily of membrane transporters which are known as the mitochondrial carrier family (MCF) or the solute carrier family 25 (SLC25 protein family). In humans, the MCF has 53 members encoded by nuclear genes. Members of the SLC25 family of transporters, which is the largest group of solute carriers, are also known as mitochondrial carriers (MCs). Because MCs are nuclear-coded proteins, they must be imported into the IMM. When compared with normal cells, the mitochondria of cancer cells exhibit significantly increased transmembrane potentials and a number of their transporters are altered. SLC25 members were identified as potential biomarkers for various cancers. The objective of this review is to summarize what is currently known about the involvement of mitochondrial SLC25 carriers in associated diseases. This review suggests that the SLC25 family could be used for the development of novel points of attack for targeted cancer therapy.
线粒体膜间代谢物的转运是一个至关重要的过程，由内膜高度控制和调节。多种代谢物、核苷酸和辅因子通过膜转运蛋白超家族穿过线粒体内膜（IMM）转运，这些蛋白超家族被称为线粒体载体家族（MCF）或溶质载体家族 25（SLC25 蛋白家族）。在人类中，MCF 由核基因编码的 53 个成员组成。溶质载体家族 25（SLC25）转运蛋白家族是最大的溶质载体家族之一，也被称为线粒体载体（MCs）。由于 MCs 是核编码蛋白，它们必须被导入 IMM。与正常细胞相比，癌细胞的线粒体表现出明显增加的跨膜电势，并且它们的一些转运蛋白发生改变。SLC25 成员被鉴定为各种癌症的潜在生物标志物。本综述的目的是总结目前已知的线粒体 SLC25 载体在相关疾病中的作用。本综述表明，SLC25 家族可用于开发针对癌症的新型靶向治疗靶点。
