Jabalameli Leila, Beigverdi Reza, Ranjbar Hamidreza Hagh, Pouriran Ramin, Jabalameli Fereshteh, Emaneini Mohammad
Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Microb Drug Resist. 2021 Jan;27(1):73-86. doi: 10.1089/mdr.2019.0396. Epub 2020 May 22.
Despite the existence of discrete and varied studies regarding extended-spectrum β-lactamase-producing (ESBL-EC) in Iran, a comprehensive analysis on the prevalence of ESBL-EC has not yet been carried out. The current study analyzed published data regarding ESBL-EC in different regions of Iran to gain insight into this significant subject. A meta-analysis was performed using Comprehensive Meta-Analysis Software (version 2.2; Biostat) to determine the prevalence of ESBL-EC in Iran. A web-based search was conducted in electronic databases, including PubMed, Scopus, and Web of Sciences. The eligibility of articles published between 2008 and 2018 was assessed, and relevant data were extracted for statistical analysis. A random-effects model was used based on the heterogeneity test. Publication bias was determined using Begg's rank correlation and Egger's weighted regression methods. Among 31,135 studies examined, 61 met inclusion criteria and were included for review. Iran's overall pooled proportion of ESBL-EC was 43.2% (confidence interval [95% CI] 39.2-47.3), and the overall heterogeneity () between studies was significantly high (93.5%, = 0.00). The most prevalent of ESBLs in was CTX-M and TEM, with prevalence of 31.2% (95% CI 25.4-37.6), 27.6% (95% CI 22.7-33.2), respectively. The available studies show a high rate of ESBL-EC in Iran. This result highlights a need for appropriate and rapid methods for estimating ESBL infection, which can help our understanding of the actual epidemiology of ESBL and provide protocols for the prevention and control of infection.
尽管伊朗存在关于产超广谱β-内酰胺酶（ESBL-EC）的离散且多样的研究，但尚未对ESBL-EC的流行情况进行全面分析。本研究分析了伊朗不同地区有关ESBL-EC的已发表数据，以深入了解这一重要课题。使用综合荟萃分析软件（版本2.2；Biostat）进行荟萃分析，以确定伊朗ESBL-EC的流行率。在包括PubMed、Scopus和科学网在内的电子数据库中进行了基于网络的搜索。评估了2008年至2018年发表文章的合格性，并提取相关数据进行统计分析。基于异质性检验使用随机效应模型。使用Begg秩相关和Egger加权回归方法确定发表偏倚。在审查的31,135项研究中，61项符合纳入标准并被纳入综述。伊朗ESBL-EC的总体合并比例为43.2%（置信区间[95%CI]39.2 - 47.3），研究之间的总体异质性（）显著较高（93.5%，= 0.00）。ESBLs中最常见的是CTX-M和TEM，流行率分别为31.2%（95%CI 25.4 - 37.6）、27.6%（95%CI 22.7 - 33.2）。现有研究表明伊朗ESBL-EC的发生率很高。这一结果凸显了需要适当且快速的方法来估计ESBL感染，这有助于我们了解ESBL的实际流行病学情况，并提供感染预防和控制方案。
