Department of Radiation Oncology, James Graham Brown Cancer Center, University of Louisville School of Medicine, 529 S. Jackson St., Louisville, KY 40202, United States of America.
Department of Bioinformatics & Biostatistics, University of Louisville School of Public Health and Information Sciences, 485 E. Gray St., Louisville, KY 40202, United States of America.
Gynecol Oncol. 2020 Aug;158(2):446-451. doi: 10.1016/j.ygyno.2020.05.011. Epub 2020 May 23.
The goal of this study was to assess how the incidence and mortality of cervical cancer in Kentucky has changed from 1995 through 2017. Additionally, trends in incidence and mortality across different geographic areas and between different races were evaluated.
Age-adjusted annual incidence and mortality rates for cervical cancer were collected from the Kentucky Cancer Registry (KCR). A quadratic fit model was used to evaluate changes in the incidence and mortality over time and to compare differences in cervical cancer incidence and mortality by: 1) rural versus urban counties, 2) Appalachian versus non-Appalachian counties, and 3) black versus white women.
Overall, the incidence of cervical cancer has significantly decreased throughout Kentucky since 1995. When comparing different geographic regions, the incidence was 14% and 23% higher in rural and Appalachian counties, respectively, compared to urban and non-Appalachian counties (p < 0.0001) throughout the study period. The incidence of cervical cancer was significantly higher in black women compared to white women from 1995 through 2007, but since 2008 there has been no significant difference in cervical cancer incidence based on race. Similar to incidence rates, mortality from cervical cancer was 29% higher in Appalachia (p = 0.0004) throughout the studied time period. Black women had higher age-adjusted mortality than white women until 2012, but since that time there has not been a significant difference in cervical cancer mortality based on race.
Women residing in rural and Appalachian Kentucky have higher cervical cancer incidence and mortality rates.
本研究旨在评估肯塔基州宫颈癌的发病率和死亡率从 1995 年至 2017 年的变化情况。此外，还评估了不同地理区域和不同种族之间的发病率和死亡率趋势。
从肯塔基癌症登记处（KCR）收集了宫颈癌的年龄调整年发病率和死亡率。使用二次拟合模型来评估发病率和死亡率随时间的变化，并比较不同地区和不同种族之间宫颈癌发病率和死亡率的差异：1）农村与城市县，2）阿巴拉契亚与非阿巴拉契亚县，3）黑人和白人妇女。
总体而言，自 1995 年以来，肯塔基州的宫颈癌发病率明显下降。在比较不同地理区域时，农村和阿巴拉契亚县的发病率分别比城市和非阿巴拉契亚县高 14%和 23%（p<0.0001），整个研究期间都是如此。从 1995 年至 2007 年，黑人妇女的宫颈癌发病率明显高于白人妇女，但自 2008 年以来，种族之间的宫颈癌发病率没有显著差异。与发病率相似，阿巴拉契亚地区的宫颈癌死亡率高 29%（p=0.0004），整个研究期间都是如此。黑人妇女的年龄调整死亡率一直高于白人妇女，直到 2012 年，但此后，种族之间的宫颈癌死亡率没有显著差异。
居住在肯塔基州农村和阿巴拉契亚地区的妇女宫颈癌发病率和死亡率较高。
