锌缺乏兔颊黏膜上皮细胞迁移、腺苷酸环化酶及膜被颗粒的研究，包括异丙肾上腺素的影响。
Studies on cell migration, adenylate cyclase and membrane-coating granules in the buccal epithelium of the zinc-deficient rabbit, including the influence of isoproterenol.
作者信息
Chen S Y
机构信息
Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140.
出版信息
Arch Oral Biol. 1988;33(9):645-51. doi: 10.1016/0003-9969(88)90118-5.
Cell migration was slightly increased; cytochemical reaction deposits of adenylate cyclase and the area density of membrane-coating granules (MCG) were significantly increased. Upon isoproterenol stimulation, the MCG area density was significantly increased, whereas the cell migration rate was unchanged. Thus in zinc deficiency, there may be a simultaneous increase in the production and secretion of MCGs, in adenylate cyclase activity, and in cell migration. The non-significantly increased cell migration rate may not keep pace with the significantly increased cell-production rate, resulting in thickening of the epithelium.
细胞迁移略有增加；腺苷酸环化酶的细胞化学反应沉积物和膜包被颗粒（MCG）的面积密度显著增加。在异丙肾上腺素刺激下，MCG面积密度显著增加，而细胞迁移率未改变。因此，在锌缺乏时，MCG的产生和分泌、腺苷酸环化酶活性以及细胞迁移可能同时增加。细胞迁移率增加不显著可能跟不上细胞产生率的显著增加，从而导致上皮增厚。
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