二甲双胍通过细胞周期阻滞和延迟DNA损伤修复增加宫颈癌细胞的放射敏感性。
Buformin increases radiosensitivity in cervical cancer cells via cell-cycle arrest and delayed DNA-damage repair.
作者信息
Chen Ling, Zhang Ting, Liu Qiuli, Tang Mei, Yang Yu'e, Wang Yuan, Qiu Haifeng, Yu Jinjin
机构信息
Department of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Wuxi Medical College, Jiangnan University, Wuxi 214000, China.
出版信息
Exp Biol Med (Maywood). 2018 Oct;243(14):1133-1140. doi: 10.1177/1535370218813320.
Abstract
Our idea originated in the thought of discovering new effects of old drugs. Although this study is a basic research, it is very close to clinical treatment. Flow cytometry and immunofluorescence were used to verify that buformin increases radiosensitivity. We aimed to address one of the thorniest problems in treatment process. Based on discovering new effects of old drugs, it is feasible to use buformin as an anticancer drug in clinical application. This will provide new ideas for clinical treatment.
摘要
我们的想法源于发现旧药新疗效的念头。尽管这项研究是基础研究，但它与临床治疗密切相关。我们使用流式细胞术和免疫荧光法来验证二甲双胍可提高放射敏感性。我们旨在解决治疗过程中最棘手的问题之一。基于发现旧药的新疗效，在临床应用中使用二甲双胍作为抗癌药物是可行的。这将为临床治疗提供新思路。
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