Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Curr Drug Deliv. 2020;17(8):651-674. doi: 10.2174/1567201817666200527133719.
Natural polysaccharides, as well as biopolymers, are now days widely developed for targeting colon cancer using various drug delivery systems. Currently, healing conformations are being explored that can efficiently play a multipurpose role. Owing to the capability of extravagance colonic diseases with the least adverse effects, biopolymers for site specific colon delivery have developed an increased curiosity over the past decades. Inulin (INU) was explored for its probable application as an entrapment material concerning its degradation by enzymes in the colonic microflora and its drug release behavior in a sustained and controlled manner. INU is a polysaccharide and it consists of 2 to 1 linkage having an extensive array of beneficial uses such as a carrier for delivery of therapeutic agents as an indicative/investigative utensil or as a dietary fiber with added well-being aids. In the main, limited research, as well as information, is available on the delivery of therapeutic agents using inulin specifically for colon cancer because of its capability to subsist in the stomach's acidic medium. This exceptional steadiness and robustness properties are exploited in numerous patterns to target drugs securely for the management of colonic cancer, where they effectively act and kills colonic tumor cells easily. In this review article, recent efforts and inulin-based nano-technological approaches for colon cancer targeting are presented and discussed.
天然多糖和生物聚合物如今被广泛开发,用于通过各种药物传递系统靶向结肠癌。目前,正在探索能够有效发挥多种用途的治疗方法。由于生物聚合物在治疗结肠疾病方面具有最小的副作用,因此在过去几十年中,用于结肠部位特定药物传递的生物聚合物引起了人们越来越多的兴趣。菊粉(INU)因其在结肠微生物群中的酶降解能力及其在持续和控制释放药物方面的行为而被探索用作包埋材料。INU 是一种多糖,由 2 到 1 的键合组成,具有广泛的有益用途,例如作为治疗剂的载体,作为指示/研究工具,或作为膳食纤维,具有额外的健康益处。由于 INU 能够在胃的酸性环境中存活,因此针对结肠癌使用 INU 传递治疗剂的相关研究和信息非常有限。这种特殊的稳定性和坚固性特性被广泛应用于多种模式,以安全地将药物靶向用于治疗结肠癌症,在那里它们可以有效地作用并轻易杀死结肠肿瘤细胞。在这篇综述文章中,我们介绍并讨论了针对结肠癌的 INU 纳米技术的最新研究进展。