去甲肾上腺素转运体G1287A多态性与重度抑郁症、抗抑郁反应之间的关联：一项荟萃分析。

The association between polymorphism of norepinephrine transporter G1287A and major depressive disorder, antidepressant response: a meta-analysis.

作者信息

Zhao Xiaofeng, Song Chuanfu, Wang Na, He Jin, Yang Xueping, Zhang Huijie, Deng Yajie, He Yi, Liu Yujia, Li Hengfen, Cao Suxia

机构信息

Department of Psychiatry, Zhengzhou University First Affiliated Hospital, Zhengzhou, Henan Province.

Department of Psychiatry, the Fourth Hospital of Wuhu city, Wuhu, Anhui Province.

出版信息

Psychiatr Genet. 2020 Aug;30(4):101-109. doi: 10.1097/YPG.0000000000000254.

DOI:10.1097/YPG.0000000000000254

PMID:32459709

Abstract

OBJECTIVES

Massive research has examined the cause of major depressive disorder (MDD) and accumulating evidence has revealed that the gene for the norepinephrine transporter (NET) is involved in MDDs etiology as well as the antidepressant response. The G1287A (rs5569, GRCh38, Chromosome 16, 55697923) is located in the exon 9 region of the SLC6A2 gene. It was found to be connected with MDD and antidepressant response in people of different genetic ancestries. However, the results are still inconsistent.

METHODS

A meta-analysis was conducted to evaluate the overall association of rs5569 polymorphisms with MDD and the antidepressant response.

RESULTS

Sixteen articles that studied the connection between the G1287A polymorphism and MDD or antidepressant response were identified, and their outcomes revealed there was a significant connection between the polymorphisms and MDD and antidepressant response. Our study indicated that the GG genotype may be a protection factor against the development of MDD [odds ratio (OR = 0.78, 95% confidence interval (CI) = 0.64-0.96, P = 0.02 for Asian population; OR = 0.79, 95% CI = 0.63-0.98, P = 0.03 for Han Chinese population] while the GG genotype had a worse antidepressant response (OR = 0.49, 95% CI = 0.25-0.94, P = 0.03).

CONCLUSIONS

NET G1287A polymorphisms are involved in the etiology of MDD and antidepressant response.

摘要

目的

大量研究探讨了重度抑郁症（MDD）的病因，越来越多的证据表明，去甲肾上腺素转运体（NET）基因与MDD的病因以及抗抑郁反应有关。G1287A（rs5569，GRCh38，16号染色体，55697923）位于SLC6A2基因的外显子9区域。研究发现，它与不同遗传血统人群的MDD和抗抑郁反应有关。然而，结果仍不一致。

方法

进行荟萃分析，以评估rs5569多态性与MDD和抗抑郁反应之间的总体关联。

结果

共纳入16篇研究G1287A多态性与MDD或抗抑郁反应之间关系的文章，结果显示该多态性与MDD和抗抑郁反应之间存在显著关联。我们的研究表明，GG基因型可能是预防MDD发生的保护因素[亚洲人群的比值比（OR）=0.78，95%置信区间（CI）=0.64-0.96，P=0.02；汉族人群的OR=0.79，95%CI=0.63-0.98，P=0.03]，而GG基因型的抗抑郁反应较差（OR=0.49，95%CI=0.25-0.94，P=0.03）。