伏隔核壳：一种具有神经精神障碍的耐药性癫痫的潜在靶点。
Nucleus accumbens shell: A potential target for drug-resistant epilepsy with neuropsychiatric disorders.
机构信息
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, China; The First Clinical Medicine College, Southern Medical University, China; Neural Networks Surgery Team, Southern Medical University, China.
The First Clinical Medicine College, Southern Medical University, China; Neural Networks Surgery Team, Southern Medical University, China.
出版信息
Epilepsy Res. 2020 Aug;164:106365. doi: 10.1016/j.eplepsyres.2020.106365. Epub 2020 May 12.
The nucleus accumbens (NAc) is an important component of the ventral striatum, involving motivational and emotional processes, limbic-motor interfaces. Recently, experimental and clinical data have shown that NAc, particularly NAc shell (NAcs), participates in ictogenesis and epileptogensis in drug-resistant epilepsy (DRE). Therefore, we summarize the existing literature on NAcs and potential role in epilepsy, from the bench to the clinic. Connection abnormalities between NAcs and remainings, degeneration of NAc neurons, and an aberrant distribution of neuroactive substances have been reported in patients with DRE. These changes may be underlying the pathophysiological mechanism of the involvement of NAcs in DRE. Furthermore, alterations in NAcs may also be involved in neuropsychiatric disorders in patients with DRE. These observational studies demonstrate the multiple properties of NAcs and the complex relationship between the limbic system and DRE with neuropsychiatric disorders. NAcs can be a potential target for DBS and stereotactic lesioning to manage DRE with neuropsychiatric disorders. Future studies are warranted to further clarify the role of NAcs in epilepsy.
伏隔核（NAc）是腹侧纹状体的重要组成部分，涉及动机和情绪过程、边缘运动接口。最近，实验和临床数据表明，NAc，特别是 NAc 壳（NAcs），参与耐药性癫痫（DRE）的致痫和癫痫发生。因此，我们从基础到临床，总结了关于 NAc 及其在癫痫中潜在作用的现有文献。在 DRE 患者中，已经报道了 NAc 与剩余部分之间的连接异常、NAc 神经元变性以及神经活性物质的异常分布。这些变化可能是 NAc 参与 DRE 的病理生理机制的基础。此外，NAc 的改变也可能与 DRE 患者的神经精神障碍有关。这些观察性研究表明了 NAc 的多种特性以及边缘系统与 DRE 伴发神经精神障碍之间的复杂关系。NAc 可以成为 DBS 和立体定向神经外科手术治疗伴有神经精神障碍的 DRE 的潜在靶点。未来的研究需要进一步阐明 NAc 在癫痫中的作用。
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