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Does the breakdown of the detoxification system for aldehydes as a result of aldose reductase upregulation lead to alcohol-induced liver injury in humans and mice?

作者信息

Hotta Nigishi, Kawamura Takahiko, Umemura Toshitaka

机构信息

Department of Endocrine Internal Medicine, Chubu Rosai Hospital, Japan Organization of Occupational Health and Safety, Nagoya, Japan.

Preventive Medical Center, Chubu Rosai Hospital, Japan Organization of Occupational Health and Safety, Nagoya, Japan.

出版信息

J Diabetes Investig. 2020 Nov;11(6):1426-1430. doi: 10.1111/jdi.13305. Epub 2020 Jul 7.

DOI:10.1111/jdi.13305
PMID:32460409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7610110/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/7610110/4e6563ff8d34/JDI-11-1426-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/7610110/5e86c79223d1/JDI-11-1426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/7610110/4e6563ff8d34/JDI-11-1426-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/7610110/5e86c79223d1/JDI-11-1426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/7610110/4e6563ff8d34/JDI-11-1426-g002.jpg

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2
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J Diabetes Investig. 2020 Jul;11(4):786-788. doi: 10.1111/jdi.13190. Epub 2020 Jan 7.
3
Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides.
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N Engl J Med. 2019 Nov 7;381(19):1866-1869. doi: 10.1056/NEJMcibr1910023.
4
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Curr Drug Targets. 2020;21(6):599-609. doi: 10.2174/1389450120666191007111712.
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Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.尿酸激活醛糖还原酶和多元醇途径，导致内源性果糖和脂肪生成，从而导致大鼠脂肪肝的发生。
J Biol Chem. 2019 Mar 15;294(11):4272-4281. doi: 10.1074/jbc.RA118.006158. Epub 2019 Jan 16.
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