Cilla Nicolas, Domitien Léa, Arrada Neila, Chiffre Delphine, Mahe Perrine, Vincent Laure, Aguilar-Martinez Patricia, Foulongne Vincent
Department of Clinical Hematology, Montpellier University Hospital, 34295, Montpellier, France.
Division of Hematologic Diseases, Department of Pediatrics, Montpellier University Hospital, University Montpellier, Montpellier, France.
IDCases. 2020 May 11;21:e00802. doi: 10.1016/j.idcr.2020.e00802. eCollection 2020.
Acute parvovirus B19 infection may lead to erythroblastopenia crisis in patients with underlying red blood cells disorders. We report herein an uncommon concomitant transient aplastic crisis in a mother and her daughter, both affected by hereditary spherocytosis. The diagnosis was confirmed by the detection of a very high parvovirus B19 DNA load in both the mother's and daughter's sera, associated with the presence of parvovirus B19 specific immunoglobulin-M antibodies. This rapid etiologic diagnosis allowed to save bone marrow sampling, although blood transfusion was required regarding the severe anemia associated with pancytopenia. Our observation illustrates first line parvovirus B19 hypothesis in the context of transient aplastic crisis and that contagiousness in household contacts should be considered in family with a medical history of red blood cell pathology.
急性B19细小病毒感染可能导致患有潜在红细胞疾病的患者发生成红细胞减少危象。我们在此报告一位母亲和她女儿同时发生罕见的短暂再生障碍危象的病例，她们均患有遗传性球形红细胞增多症。通过检测母亲和女儿血清中非常高的B19细小病毒DNA载量，并结合B19细小病毒特异性免疫球蛋白M抗体的存在，确诊了该病例。尽管由于全血细胞减少相关的严重贫血需要输血，但这种快速的病因诊断避免了骨髓穿刺取样。我们的观察结果表明，在短暂再生障碍危象的情况下，B19细小病毒是首要考虑因素，并且对于有红细胞疾病病史的家庭，应考虑家庭接触中的传染性。
