Baklavadzhian O G, Darbinian A G, Taturian I Kh
Fiziol Zh SSSR Im I M Sechenova. 1988 Nov;74(11):1554-63.
Effects of acute and chronic arterial hypertension on self-stimulation operant behaviour were studied in cats and rats. Small doses of noradrenaline facilitated the self-stimulation, whereas high doses depressed or stopped it. The depressive effect was accompanied by an obvious increase in the blood pressure. Chronic neurogenic hypertension can be induced by means of overloading the higher nervous system. A marked suppression of self-stimulation behaviour was found in chronic hypertensive rats. Decrease of the arterial pressure induced with an anti-hypertensive drug (catapresan) resulted in a temporary recovery of self-stimulation reaction. Baroafferent mechanisms of inhibition of positive emotional structures of the hypothalamus are discussed.
研究了急慢性动脉高血压对猫和大鼠自我刺激操作性行为的影响。小剂量去甲肾上腺素促进自我刺激，而大剂量则抑制或终止自我刺激。抑制作用伴随着血压明显升高。慢性神经源性高血压可通过使高级神经系统负荷过重诱发。在慢性高血压大鼠中发现自我刺激行为受到明显抑制。用抗高血压药物（可乐定）降低动脉血压导致自我刺激反应暂时恢复。讨论了抑制下丘脑积极情绪结构的压力感受器传入机制。
