Université Lille, Centre National de la Recherche Scientifique, Inserm, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1019, Unité Mixte de Recherche 8204, Center for Infection and Immunity of Lille, Lille, France.
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Clin Infect Dis. 2020 Dec 3;71(9):2521-2526. doi: 10.1093/cid/ciaa651.
To commemorate the 100th anniversary of the Nobel prize being awarded to Jules Bordet, the discoverer of Bordetella pertussis, the 12th International Bordetella Symposium was held from 9 to 12 April 2019 at the Université Libre de Bruxelles, where Jules Bordet studied and was Professor of Microbiology. The symposium attracted more than 300 Bordetella experts from 34 countries. They discussed the latest epidemiologic data and clinical aspects of pertussis, Bordetella biology and pathogenesis, immunology and vaccine development, and genomics and evolution. Advanced technological and methodological tools provided novel insights into the genomic diversity of Bordetella and a better understanding of pertussis disease and vaccine performance. New molecular approaches revealed previously unrecognized complexity of virulence gene regulation. Innovative insights into the immune responses to infection by Bordetella resulted in the development of new vaccine candidates. Such discoveries will aid in the design of more effective approaches to control pertussis and other Bordetella-related diseases.
为纪念发现百日咳博德特氏菌的朱尔斯·博尔德特（Jules Bordet）获得诺贝尔奖 100 周年，第 12 届国际博德特氏菌研讨会于 2019 年 4 月 9 日至 12 日在朱尔斯·博尔德特（Jules Bordet）学习和任教的布鲁塞尔自由大学举行。来自 34 个国家的 300 多名博德特氏菌专家参加了研讨会。他们讨论了百日咳的最新流行病学数据和临床方面、博德特氏菌生物学和发病机制、免疫学和疫苗开发以及基因组学和进化。先进的技术和方法工具为博德特氏菌的基因组多样性提供了新的见解，并更好地了解了百日咳疾病和疫苗性能。新的分子方法揭示了先前未被识别的毒力基因调控复杂性。对博德特氏菌感染免疫反应的创新性见解导致了新疫苗候选物的开发。这些发现将有助于设计更有效的方法来控制百日咳和其他与博德特氏菌相关的疾病。
