候选多态性与炎症性肠病易感性：系统评价和荟萃分析。
Candidate polymorphisms and susceptibility to inflammatory bowel disease: A systematic review and meta-analysis.
机构信息
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, PR China.
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, PR China.
出版信息
Gene. 2020 Aug 30;753:144814. doi: 10.1016/j.gene.2020.144814. Epub 2020 May 26.
AIMS
The goal of our study is to investigate the contribution of the 13 single-nucleotide polymorphisms to inflammatory bowel disease (IBD), including Crohn's disease (CD) and Ulcerative colitis (UC).
METHODS
A total of 44 articles were retrieved from bibliographic databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Through a comprehensive filtering procedure, 13 single-nucleotide polymorphisms were collected in the meta-analysis, which was done by Review Manager 5.0.
RESULTS
After a systematic filtration, there were 13 single-nucleotide polymorphisms (SNPs) from 44 articles involved in our meta-analysis. Our results demonstrated that 3 SNPs were found to be significantly associated with CD/UC/IBD: IRF5 rs4728142 (UC: OR = 1.21, 95% CI = 1.09-1.35, P = 0.0003; OR = 1.30, 95% CI = 1.08-1.57, P = 0.006 in Asian), PTGER4 rs4613763 (CD: the overall OR = 1.28, 95% CI = 1.01-1.64, P = 0.04; IBD: OR = 1.31, 95% CI = 1.04-1.65, P = 0.02), IL12B rs6887695 (CD: the overall OR = 1.17, 95% CI = 1.06-1.30, P = 0.002; UC: the overall OR = 1.13, 95% CI = 1.01-1.26, P = 0.03; IBD: the overall OR = 1.15, 95% CI = 1.06-1.24, P = 0.0009).
CONCLUSION
Our meta-analyses have indicated the significant associations between SNPs (IRF5 rs4728142, PTGER4 rs4613763, and IL12B rs6887695) and CD/UC/IBD.
目的
本研究旨在探讨 13 个单核苷酸多态性（SNP）对炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC）的贡献。
方法
从包括 PubMed、Embase、SpringerLink、Web of Science、中国国家知识基础设施（CNKI）和万方在内的文献数据库中检索了 44 篇文章。通过综合筛选程序，在荟萃分析中收集了 13 个单核苷酸多态性，使用 Review Manager 5.0 进行分析。
结果
经过系统筛选，有 13 个单核苷酸多态性（SNP）来自 44 篇文章纳入我们的荟萃分析。我们的结果表明，有 3 个 SNP 与 CD/UC/IBD 显著相关：IRF5 rs4728142（UC：OR=1.21，95%CI=1.09-1.35，P=0.0003；OR=1.30，95%CI=1.08-1.57，P=0.006，亚洲人群），PTGER4 rs4613763（CD：总体 OR=1.28，95%CI=1.01-1.64，P=0.04；IBD：OR=1.31，95%CI=1.04-1.65，P=0.02），IL12B rs6887695（CD：总体 OR=1.17，95%CI=1.06-1.30，P=0.002；UC：总体 OR=1.13，95%CI=1.01-1.26，P=0.03；IBD：总体 OR=1.15，95%CI=1.06-1.24，P=0.0009）。
结论
本荟萃分析表明，SNP（IRF5 rs4728142、PTGER4 rs4613763 和 IL12B rs6887695）与 CD/UC/IBD 之间存在显著关联。
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