Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China; Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, PR China.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Chemosphere. 2020 Oct;256:127108. doi: 10.1016/j.chemosphere.2020.127108. Epub 2020 May 18.
We aimed to assess if snoring and ambient air pollutants were jointly associated with prevalent hypertension in a cross-sectional study.
A total of 28440 participants aged 18-79 years were obtained from the Henan Rural Cohort. Snoring evaluated using Pittsburgh sleep quality index (PSQI) scale was classified into 'Never', '<3 times/week' and '≥3 times/week' groups. Concentrations of air pollutants (PM, PM, PM, and NO) were evaluated by a satellite-based spatiotemporal model. The independent and joint associations between snoring and air pollutants on prevalence of hypertension were analyzed by logistic regression models.
The mean age of all participants was 56.0 ± 12.2 years. The frequencies and prevalence of participants with hypertension were 3666 (32.39%) in men and 5576(32.57%) in women, respectively. The odds ratio (OR) and 95% confidence interval (CI) of participants with snoring frequency of <3 times/week, ≥3 times/week was 1.10(1.02-1.20), and 1.15(1.08-1.23) for hypertension, compared to those without snoring. Participants with a snoring (≥3 times/week) and higher exposure concentrations of PM, PM, PM, and NO had 2.58-fold(95% CI: 2.30-2.90), 3.03-fold(95% CI: 2.69-3.41), 2.89-fold(95% CI: 2.57-3.25) and 2.75-fold(95% CI: 2.44-3.10) for hypertension, compared to those without snoring and low concentrations of air pollutants. Additionally, participants with high PM and ≥3 times/week snoring (OR: 1.32, 95% CI: 1.18-1.48) was at a higher likelihood for prevalent hypertension, compared to those without snoring and with high PM.
Snoring and high ambient air pollutants might be important predictors of hypertension, and higher concentration of PM might aggravate the association between snoring and hypertension.
本研究旨在通过横断面研究评估打鼾和环境空气污染物与高血压患病率的联合相关性。
本研究共纳入了 28440 名年龄在 18-79 岁的河南农村队列研究参与者。使用匹兹堡睡眠质量指数（PSQI）量表评估打鼾情况，将其分为“从不”、“每周<3 次”和“每周≥3 次”组。通过基于卫星的时空模型评估空气污染物（PM2.5、PM10、PM2.5 和 NO）浓度。使用 logistic 回归模型分析打鼾和空气污染物对高血压患病率的独立和联合关联。
所有参与者的平均年龄为 56.0±12.2 岁。男性高血压患者频率和患病率分别为 3666（32.39%），女性为 5576（32.57%）。与不打鼾者相比，每周打鼾频率<3 次和≥3 次的参与者高血压的比值比（OR）和 95%置信区间（CI）分别为 1.10（1.02-1.20）和 1.15（1.08-1.23）。与不打鼾者相比，每周打鼾（≥3 次）且 PM、PM10、PM2.5 和 NO 暴露浓度较高的参与者发生高血压的风险分别增加 2.58 倍（95%CI：2.30-2.90）、3.03 倍（95%CI：2.69-3.41）、2.89 倍（95%CI：2.57-3.25）和 2.75 倍（95%CI：2.44-3.10）。此外，与不打鼾且 PM 水平较高的参与者相比，PM 水平较高且每周打鼾≥3 次的参与者发生高血压的可能性更高（OR：1.32，95%CI：1.18-1.48）。
打鼾和环境空气污染物可能是高血压的重要预测因素，较高的 PM 浓度可能会加重打鼾与高血压之间的关联。
