• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-κB/TS Signaling in Colorectal Cancer.

作者信息

Li Peilong, Zhang Xin, Wang Lili, Du Lutao, Yang Yongmei, Liu Tong, Li Chen, Wang Chuanxin

出版信息

Mol Ther Nucleic Acids. 2020 Jun 5;20:879-880. doi: 10.1016/j.omtn.2020.05.016. Epub 2020 May 25.

DOI:10.1016/j.omtn.2020.05.016
PMID:32464550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7256442/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/114b/7256442/ddc17e293250/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/114b/7256442/ddc17e293250/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/114b/7256442/ddc17e293250/gr3.jpg

相似文献

1
lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-κB/TS Signaling in Colorectal Cancer.长链非编码RNA HOTAIR通过抑制miR-218和激活NF-κB/TS信号通路促进结直肠癌对5-氟尿嘧啶的耐药性。
Mol Ther Nucleic Acids. 2020 Jun 5;20:879-880. doi: 10.1016/j.omtn.2020.05.016. Epub 2020 May 25.
2
lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-κB/TS Signaling in Colorectal Cancer.长链非编码RNA HOTAIR通过抑制miR-218和激活NF-κB/TS信号通路促进结直肠癌对5-氟尿嘧啶的耐药性。
Mol Ther Nucleic Acids. 2017 Sep 15;8:356-369. doi: 10.1016/j.omtn.2017.07.007. Epub 2017 Jul 8.
3
HOTAIR contributes to chemoresistance by activating NF-κB signaling in small-cell lung cancer.HOTAIR通过激活小细胞肺癌中的NF-κB信号通路促进化疗耐药。
Int J Clin Exp Pathol. 2019 Aug 1;12(8):2997-3004. eCollection 2019.
4
LncRNA HOTAIR is a Prognostic Biomarker for the Proliferation and Chemoresistance of Colorectal Cancer via MiR-203a-3p-Mediated Wnt/ß-Catenin Signaling Pathway.长链非编码RNA HOTAIR通过miR-203a-3p介导的Wnt/β-连环蛋白信号通路成为结直肠癌增殖和化疗耐药的预后生物标志物。
Cell Physiol Biochem. 2018;46(3):1275-1285. doi: 10.1159/000489110. Epub 2018 Apr 16.
5
NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer.核因子-κB- HOX转录反义RNA轴在卵巢癌中连接DNA损伤反应、化疗耐药性和细胞衰老。
Oncogene. 2016 Oct 13;35(41):5350-5361. doi: 10.1038/onc.2016.75. Epub 2016 Apr 4.
6
LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activating NF-κB pathway.长链非编码RNA-HOTAIR通过激活核因子κB通路促进脂多糖诱导的脓毒症小鼠心肌细胞中肿瘤坏死因子-α的产生。
Biochem Biophys Res Commun. 2016 Feb 26;471(1):240-6. doi: 10.1016/j.bbrc.2016.01.117. Epub 2016 Jan 21.
7
Expression profile of long noncoding RNA (HOTAIR) and its predicted target miR-17-3p in LPS-induced inflammatory injury in human articular chondrocyte C28/I2 cells.长链非编码RNA（HOTAIR）及其预测靶点miR-17-3p在脂多糖诱导的人关节软骨细胞C28/I2细胞炎性损伤中的表达谱
Int J Clin Exp Pathol. 2017 Sep 1;10(9):9146-9157. eCollection 2017.
8
Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR-136-5p and long non-coding RNA HOTAIR in cuprizone-induced demyelination.柳氮磺胺吡啶通过 miR-136-5p 和长链非编码 RNA HOTAIR 的竞争内源性 RNA 效应改变小胶质细胞表型在铜诱导脱髓鞘中的作用。
Biochem Pharmacol. 2018 Sep;155:110-123. doi: 10.1016/j.bcp.2018.06.028. Epub 2018 Jun 23.
9
Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/β-catenin signaling pathways by up-regulating miR-34a.敲低长链非编码 RNA HOTAIR 通过上调 miR-34a 抑制 PI3K/Akt 和 Wnt/β-catenin 信号通路抑制胃癌细胞顺铂耐药。
Int J Biol Macromol. 2018 Feb;107(Pt B):2620-2629. doi: 10.1016/j.ijbiomac.2017.10.154. Epub 2017 Oct 26.
10
LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages.长链非编码 RNA HOTAIR 调控巨噬细胞中脂多糖诱导的细胞因子表达和炎症反应。
Sci Rep. 2018 Oct 23;8(1):15670. doi: 10.1038/s41598-018-33722-2.

引用本文的文献

1
Overexpression of Nuclear Factor of Activated T-cells (NFAT) Transcription Factors Drives Chemoresistance and Poor Outcomes in Pancreatic Cancer.活化T细胞核因子（NFAT）转录因子的过表达驱动胰腺癌的化疗耐药性并导致不良预后。
Ann Surg Oncol. 2025 Aug 28. doi: 10.1245/s10434-025-18186-9.
2
NF-κB in inflammation and cancer.炎症与癌症中的核因子-κB
Cell Mol Immunol. 2025 Jun 25. doi: 10.1038/s41423-025-01310-w.
3
Protosappanin B enhances the chemosensitivity of 5-fluorouracil in colon adenocarcinoma by regulating the LINC00612/microRNA-590-3p/Golgi phosphoprotein 3 axis.
原苏木素B通过调控LINC00612/微小RNA-590-3p/高尔基体磷蛋白3轴增强结肠腺癌对5-氟尿嘧啶的化疗敏感性。
Discov Oncol. 2024 May 28;15(1):193. doi: 10.1007/s12672-024-01036-7.
4
Colorectal cancer: Genetic alterations, novel biomarkers, current therapeutic strategies and clinical trials.结直肠癌：遗传改变、新型生物标志物、当前治疗策略和临床试验。
Gene. 2024 Jan 20;892:147857. doi: 10.1016/j.gene.2023.147857. Epub 2023 Sep 30.
5
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis.长链非编码 RNA ENSMUST_147219 通过靶向 miR-221-5p/IRF6 轴介导缺血性急性肾损伤的进展。
Apoptosis. 2022 Aug;27(7-8):531-544. doi: 10.1007/s10495-022-01730-3. Epub 2022 May 26.
6
SFMBT1 facilitates colon cancer cell metastasis and drug resistance combined with HMG20A.SFMBT1与HMG20A共同作用促进结肠癌细胞转移和耐药。
Cell Death Discov. 2022 May 16;8(1):263. doi: 10.1038/s41420-022-01057-7.
7
LncRNA136131 suppresses apoptosis of renal tubular epithelial cells in acute kidney injury by targeting the miR-378a-3p/Rab10 axis.LncRNA136131 通过靶向 miR-378a-3p/Rab10 轴抑制急性肾损伤肾小管上皮细胞凋亡。
Aging (Albany NY). 2022 Apr 28;14(8):3666-3686. doi: 10.18632/aging.204036.
8
Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer.细胞外囊泡：结直肠癌诊断与治疗管理中的一般特征及应用价值
World J Gastrointest Oncol. 2021 Nov 15;13(11):1561-1598. doi: 10.4251/wjgo.v13.i11.1561.
9
Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p.长链非编码RNA CRART16通过海绵吸附miR-193b-5p赋予结肠癌细胞5-氟尿嘧啶抗性。
Cancer Cell Int. 2021 Nov 29;21(1):638. doi: 10.1186/s12935-021-02353-5.
10
lncRNA MCF2L-AS1/miR-105/ IL-1β Axis Regulates Colorectal Cancer Cell Oxaliplatin Resistance.长链非编码RNA MCF2L-AS1/微小RNA-105/白细胞介素-1β轴调控大肠癌细胞对奥沙利铂的耐药性
Cancer Manag Res. 2021 Nov 19;13:8685-8694. doi: 10.2147/CMAR.S313905. eCollection 2021.