Grove J, Gautheron P, Plazonnet B, Sugrue M F
Centre de Recherche, Merck Sharp & Dohme-Chibret, Riom, France.
J Ocul Pharmacol. 1988 Winter;4(4):279-90. doi: 10.1089/jop.1988.4.279.
The ocular distribution of the carbonic anhydrase inhibitors 6-hydroxybenzothiazide-2-sulphonamide (L-643,799) and 6-hydroxybenzothiophene-2-sulphonamide (L-650,719) has been investigated in albino rabbits after conjunctival administration of these compounds or related alkyl prodrugs. The ocular penetration of L-650,719 has been compared in ocular normotensive rabbits and in animals whose intraocular pressure has been experimentally elevated.
在白化兔结膜给药碳酸酐酶抑制剂6-羟基苯并噻唑-2-磺酰胺（L-643,799）和6-羟基苯并噻吩-2-磺酰胺（L-650,719）或相关烷基前药后，研究了这些化合物在眼部的分布。比较了L-650,719在眼压正常的兔和眼压经实验性升高的动物中的眼内渗透情况。
