CBIOS-Center for Research in Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologías, Campo Grande 376, 1749-024 Lisbon, Portugal.
Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcalá, Carretera Madrid-Barcelona, Km 33.100, 28805 Alcalá de Henares, Madrid, Spain.
Biomolecules. 2020 May 26;10(6):817. doi: 10.3390/biom10060817.
Zoopharmacognosy is the multidisciplinary approach of the self-medication behavior of many kinds of animals. Recent studies showed the presence of antitumoral secondary metabolites in some of the plants employed by animals and their use for the same therapeutic purposes in humans. Other related and sometimes confused term is Zootherapy, which consists on the employment of animal parts and/or their by-products such as toxins, venoms, etc., to treat different human ailments. Therefore, the aim of this work is to provide a brief insight for the use of Zoopharmacology (comprising Zoopharmacognosy and Zootherapy) as new paths to discover drugs studying animal behavior and/or using compounds derived from animals. This work is focused on the approaches related to cancer, in order to propose a new promising line of research to overcome multidrug resistance (MDR). This novel subject will encourage the use of new alternative prospective ways to find new medicines.
动物药理学是研究许多动物的自我药物治疗行为的多学科方法。最近的研究表明，一些动物所使用的植物中存在抗肿瘤次生代谢物，并且这些植物在人类中也被用于相同的治疗目的。另一个相关的、有时会混淆的术语是动物疗法，它包括使用动物的部分和/或其副产品，如毒素、毒液等，来治疗人类的各种疾病。因此，本工作旨在提供一个简要的见解，即利用动物药理学（包括动物药理学和动物疗法）作为通过研究动物行为和/或使用动物衍生化合物来发现药物的新途径。这项工作主要集中在与癌症相关的方法上，旨在提出一种克服多药耐药性（MDR）的新的有前途的研究方向。这个新颖的主题将鼓励使用新的替代方法来寻找新的药物。
