Bakhshwin Ahmed M, Gordon Ilyssa O, Brown Kathryn Bock, Liu Xiuli, Allende Daniela S
2569Cleveland Clinic, Cleveland, OH, USA.
Mississippi Baptist Medical Center, Jackson, MS, USA.
Int J Surg Pathol. 2020 Dec;28(8):835-843. doi: 10.1177/1066896920924821. Epub 2020 May 28.
OBJECTIVES.: With targeted agents, characterizing carcinomas of the gastrointestinal (GI) tract has become more important. We aim to determine the usefulness of p40 in classifying GI tract carcinomas.
METHODS.: Seventy-five GI carcinomas including 28 squamous cell carcinomas (SCC), 2 adenosquamous carcinomas (ASCA), 21 poorly differentiated carcinomas (PDCA), and 24 adenocarcinomas (AdCA; control group) were stained for p40, p63, and CK5/6. Tumors were scored from 0 to 5 based on extent of staining and marked as positive (score >2) or negative.
RESULTS.: p63 was positive in 100% of SCC/ASCA and 12.5% of AdCA. p40 was positive in 92.5% of SCC/ASCA and 4.1% of AdCA. In the PDCA subset, a panel including p63, p40, and MOC31 was the best way to accurately classify most cases.
CONCLUSIONS.: p63 and CK5/6 are more sensitive but less specific than p40 for SCC/ASCA in GI carcinomas. In PDCA, a panel approach including p63, CK5/6, and p40 may be best in classifying these cases.
随着靶向药物的出现，胃肠道（GI）癌的特征描述变得更加重要。我们旨在确定p40在胃肠道癌分类中的作用。
对75例胃肠道癌进行p40、p63和CK5/6染色，其中包括28例鳞状细胞癌（SCC）、2例腺鳞癌（ASCA）、21例低分化癌（PDCA）和24例腺癌（AdCA；对照组）。根据染色程度将肿瘤从0到5评分，并标记为阳性（评分>2）或阴性。
p63在100%的SCC/ASCA和12.5%的AdCA中呈阳性。p40在92.5%的SCC/ASCA和4.1%的AdCA中呈阳性。在PDCA亚组中，包括p63、p40和MOC31的一组指标是准确分类大多数病例的最佳方法。
在胃肠道癌的SCC/ASCA中，p63和CK5/6比p40更敏感但特异性更低。在PDCA中，包括p63、CK5/6和p40的一组方法可能是分类这些病例的最佳方法。
