人和豚鼠交叉反应性精子自身抗原与自身抗体。
Human and guinea-pig cross-reacting spermatozoa autoantigens and autoantibodies.
作者信息
D'almeida M, Voisin G A
出版信息
Clin Exp Immunol. 1977 Apr;28(1):163-72.
Cross-reactivity between human and guinea-pig spermatozoa autoanigens has been studied in two systems: (1) guinea-pig anti-autoantigens S, P and T immune sera reacting on human spermatozoa and (2) activity of human anti-sperm sera on guinea-pig spermatozoa. These assays, as well as the results of cross-absorptions in the two systems, revealed a close antigenic relationship between the two species of spermatozoa concerning the guinea-pig autoantigen S. However, there were some differences in its localization and serological manifestations in both species. The guinea-pig autoantigen T bore a more distant, though definite, relationship with human spermatozoa. No clear evidence of cross-reactivity between the two species was found for autoantigen P. At variance with autoimmune (or isoimmune) human antibodies, 'natural' human antibodies active on guinea-pig spermatozoa were absorbed by guinea-pig spleen cells.
已在两个系统中研究了人类和豚鼠精子自身抗原之间的交叉反应性
（1）豚鼠抗自身抗原S、P和T免疫血清与人类精子发生反应，以及（2）人类抗精子血清对豚鼠精子的活性。这些检测以及两个系统中的交叉吸收结果显示，就豚鼠自身抗原S而言，两种精子之间存在密切的抗原关系。然而，其在两种物种中的定位和血清学表现存在一些差异。豚鼠自身抗原T与人类精子的关系较为疏远，不过是确定的。未发现两种物种的自身抗原P之间存在交叉反应的明确证据。与自身免疫（或同种免疫）的人类抗体不同，对豚鼠精子有活性的“天然”人类抗体可被豚鼠脾细胞吸收。
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