氯化汞诱导棕色挪威大鼠产生抗肾小球基底膜抗体。
Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride.
作者信息
Sapin C, Druet E, Druet P
出版信息
Clin Exp Immunol. 1977 Apr;28(1):173-9.
Abstract
Anti-glomerular basement membrane (GBM) antibodies were induced in the Brown-Norway rat by mercuric chloride. The existence of anti-GBM antibodies was suspected because of the immunofluorescent linear pattern. It was proved because eluted antibodies from kidneys and circulating IgG had an anti-glomerular basement membrane activity. A glomerular basement membrane antigen modified by HgCl2 is probably responsible for the appearance of such antibodies. The previous demonstration of the occurrence of an immun complex type glomerulonephitis, in outbred Wistar rats, under the same experimental conditions, suggests the existence of a genetic control for this type of immune response.
摘要
通过氯化汞在棕色挪威大鼠中诱导产生抗肾小球基底膜（GBM）抗体。由于免疫荧光呈线性模式，怀疑存在抗GBM抗体。从肾脏洗脱的抗体和循环IgG具有抗肾小球基底膜活性，从而证实了这一点。由HgCl2修饰的肾小球基底膜抗原可能是此类抗体出现的原因。先前在相同实验条件下，对远交系Wistar大鼠免疫复合物型肾小球肾炎发生情况的证明，提示了这种免疫反应类型存在基因控制。
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本文引用的文献
1
2
RENAL LESIONS ASSOCIATED WITH GOLD THERAPY; LIGHT AND ELECTRON MICROSCOPIC STUDIES.与金疗法相关的肾脏病变；光镜和电镜研究
Arthritis Rheum. 1965 Feb;8:1-13. doi: 10.1002/art.1780080102.
3
Cardiac infarction and insulin antagonism.心肌梗死与胰岛素拮抗作用。
Lancet. 1963 Jun 8;1(7293):1226-8. doi: 10.1016/s0140-6736(63)91860-9.
4
Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund's complete adjuvant.通过注射异种肾小球基底膜和弗氏完全佐剂在绵羊中诱导的肾小球肾炎。
J Exp Med. 1962 Aug 1;116(2):253-72. doi: 10.1084/jem.116.2.253.
5
Studies on fluorescent antibody staining. I. Non-specific fluorescence with fluorescein-coupled sheep anti-rabbit globulins.荧光抗体染色研究。I. 荧光素偶联羊抗兔球蛋白的非特异性荧光。
J Exp Med. 1961 Jul 1;114(1):89-110. doi: 10.1084/jem.114.1.89.
6
The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.注入的辣根过氧化物酶在小鼠肾近端小管吸收的早期阶段：一种新技术的超微结构细胞化学研究
J Histochem Cytochem. 1966 Apr;14(4):291-302. doi: 10.1177/14.4.291.
7
Renal tubular lesions caused by mercuric chloride. Electron microscopic observations: degeneration of the pars recta.氯化汞引起的肾小管病变。电子显微镜观察：直部变性。
Am J Pathol. 1968 Jun;52(6):1225-77.
8
Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.用戊二醛将酶与蛋白质偶联。偶联物用于抗原和抗体的检测。
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9
10
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