人类肺癌中的circRNA-miRNA-mRNA调控网络：最新进展
circRNA-miRNA-mRNA regulatory network in human lung cancer: an update.
作者信息
Liang Zhuo-Zheng, Guo Cheng, Zou Man-Man, Meng Ping, Zhang Tian-Tuo
机构信息
1Department of Pulmonary Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630 China.
2Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
出版信息
Cancer Cell Int. 2020 May 19;20:173. doi: 10.1186/s12935-020-01245-4. eCollection 2020.
Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been studied, probed and applied into several diseases, such as cardiovascular diseases, systemic lupus erythematosus, leukemia, pulmonary tuberculosis, and cancer especially. Recently, mounting evidence has supported that circRNAs play a key role in the tumorigenesis, progress, invasion and metastasis in lung cancer. Its special structure-3'-5' covalent loop-allow it to execute several special functions in both normal eukaryotic cells and cancer cells. Our review summaries the latest studies on characteristics and biogenesis of circRNAs, and highlight the regulatory functions about miRNA sponge of lung-cancer-related circRNAs. In addition, the interaction of the circRNA-miRNA-mRNA regulatory network will also be elaborated in detail in this review. Therefore, this review can provide a new idea or strategy for further development and application in clinical setting in terms of early-diagnosis and better treatment.
环状RNA作为有前景的诊断标志物和治疗分子，已被研究、探索并应用于多种疾病，如心血管疾病、系统性红斑狼疮、白血病、肺结核，尤其是癌症。最近，越来越多的证据支持环状RNA在肺癌的肿瘤发生、进展、侵袭和转移中起关键作用。其特殊结构——3'-5'共价环——使其能够在正常真核细胞和癌细胞中发挥多种特殊功能。我们的综述总结了环状RNA的特征和生物发生的最新研究，并强调了肺癌相关环状RNA的miRNA海绵调节功能。此外，本综述还将详细阐述环状RNA- miRNA- mRNA调节网络的相互作用。因此，本综述可为肺癌早期诊断和更好治疗在临床环境中的进一步发展和应用提供新思路或策略。
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