Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, United States.
Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, 331 Fort Johnson Road, Charleston, South Carolina 29412, United States.
Environ Sci Technol. 2020 Jul 7;54(13):8158-8166. doi: 10.1021/acs.est.9b07102. Epub 2020 Jun 12.
Prenatal exposure to per- and polyfluoroalkyl substances (PFAS), a ubiquitous class of chemicals, is associated with adverse outcomes such as pre-eclampsia, low infant birth weight, and later-life adiposity. The objectives of this study were to examine PFAS levels in the placenta and identify sociodemographic risk factors in a high-risk pregnancy cohort ( = 122) in Chapel Hill, North Carolina. Of concern, PFOS, PFHxS, PFHpS, and PFUnA were detected above the reporting limit in 99, 75, 55, and 49% of placentas, respectively. Maternal race/ethnicity was associated with significant differences in PFUnA levels. While the data from this high-risk cohort did not provide evidence for an association with hypertensive disorders of pregnancy, fetal growth, or gestational age, the prevalence of detectable PFAS in the placenta suggests a need to biomonitor for exposure to PFAS during pregnancy. Future research should investigate factors underlying the differences in PFAS levels in association with a mother's race/ethnicity, as well as potential effects on pregnancy and child health.
产前暴露于全氟和多氟烷基物质（PFAS）是一类普遍存在的化学物质，与子痫前期、婴儿出生体重低和成年后肥胖等不良后果有关。本研究的目的是检测北卡罗来纳州教堂山高危妊娠队列（n=122）中胎盘内的 PFAS 水平，并确定社会人口学危险因素。值得关注的是，分别有 99%、75%、55%和 49%的胎盘内可检测到 PFOS、PFHxS、PFHpS 和 PFUnA 的浓度超过报告限值。母亲的种族/民族与 PFUnA 水平存在显著差异有关。虽然来自该高危队列的数据并未提供与妊娠高血压疾病、胎儿生长或胎龄相关的关联证据，但胎盘内可检测到 PFAS 的普遍性表明有必要在怀孕期间对 PFAS 暴露进行生物监测。未来的研究应调查与母亲种族/民族相关的 PFAS 水平差异背后的因素，以及对妊娠和儿童健康的潜在影响。
