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成人咳嗽的诊断和管理:印度环境医学协会(EMA)立场文件。

Diagnoses and management of adult cough: An Indian Environmental Medical Association (EMA) position paper.

机构信息

Emeritus Professor of Medicine, & Senior CEO, KBN Institute of Medical Sciences, Kalaburagi, Karnataka, India.

Chembur Clinic, Mumbai, India.

出版信息

Respir Med. 2020 Jul;168:105949. doi: 10.1016/j.rmed.2020.105949. Epub 2020 May 6.

Abstract

BACKGROUND

Cough is a common yet distressing symptom that results in significant health care costs from outpatient visits and related consultations.

OBJECTIVE

The understanding of the pathobiology of cough in recent times has undergone an evolution with Cough hypersensitivity syndrome (CHS) being suggested in most cases of dry cough. However, in the case of productive cough, ancillary mechanisms including impaired Mucociliary clearance, in addition to hypermucosecretory bronchospastic conditions of Smoker's cough, asthma-COPD overlap, bronchiectasis, and allergic bronchopulmonary aspergillosis, need to be critically addressed while optimizing patient care with symptomatic therapy in outpatient settings of India.

METHODS

In this review, evidence-based graded recommendations on use of antitussives - & protussives as a Position Paper were developed based on the Level and Quality of Scientific evidence as per Agency for Health Care and Quality (AHRQ) criteria listing and Expert opinions offered by a multidisciplinary EMA panel in India.

RESULTS

Management of acute or chronic cough involves addressing common issues of environmental exposures and patient concerns before instituting supportive therapy with antitussives or bronchodilatory cough formulations containing mucoactives, anti-inflammatory, or short-acting beta-2 agonist agents.

CONCLUSION

The analyses provides a real world approach to the management of acute or chronic cough in various clinical conditions with pro- or antitussive agents while avoiding their misuse in empirical settings.

摘要

背景

咳嗽是一种常见但令人不适的症状,会导致门诊就诊和相关咨询产生大量医疗费用。

目的

近年来,人们对咳嗽的病理生理学有了更深入的了解,大多数干咳病例被认为是咳嗽超敏综合征(CHS)。然而,对于湿咳病例,除了吸烟者咳嗽的黏液纤毛清除功能受损、高分泌性支气管痉挛等辅助机制外,还需要认真考虑哮喘-COPD 重叠、支气管扩张和变应性支气管肺曲霉病等情况,同时在印度的门诊环境中通过对症治疗来优化患者护理。

方法

在本综述中,根据美国医疗保健质量局(AHRQ)标准列出的科学证据水平和质量,以及印度多学科 EMA 小组提供的专家意见,制定了基于循证的、针对镇咳药和促咳药使用的分级推荐意见——这是一份立场文件。

结果

急性或慢性咳嗽的管理包括在开始支持性治疗(包括镇咳药或含有黏液溶解剂、抗炎药或短效β2 受体激动剂的支气管扩张剂咳嗽配方)之前,解决环境暴露和患者关注的常见问题。

结论

该分析提供了一种针对各种临床情况下急性或慢性咳嗽的实际管理方法,包括使用镇咳或促咳药物,同时避免在经验性治疗中滥用这些药物。

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