Department of Anatomy, All India Institute of Medical Sciences Patna, Patna, India.
Department of Anaesthesiology, All India Institute of Medical Sciences Patna, Patna, India.
Anat Rec (Hoboken). 2020 Nov;303(11):2774-2784. doi: 10.1002/ar.24461. Epub 2020 Jun 23.
A recent article published in Nature Metabolism, "A network of trans-cortical capillaries as a mainstay for blood circulation in long bones," explained the long bone vascularity. In the mouse model, the authors demonstrated hundreds of transcortical vessels (TCVs) commencing from the bone marrow and traversing the whole cortical thickness. They realized that TCVs were the same as bleeding vessels of periosteal bed observed in the human tibia and femoral epiphysis during surgery. TCVs expressed arterial or venous markers and were proposed to be the backbone of bone vascularity as 80% of arterial and 59% of venous blood distributed through them. This new evidence challenged the existence of the "cortical capillaries" stated in previous literature. We conducted a review of the existing literature to compare this model with those in earlier research. The bone vascularity model was explained by many researchers who did their work in animal models like pig, dog, rabbit, and mouse. The TCVs were identified in these animal model studies as cortical capillaries or vessels of cortical canals. Studies are scarce, showing the presence of TCVs in humans. The role of TCVs in human cortical vascularity remains ambiguous until the substantial evidence is collected in future studies.
最近发表在《自然代谢》上的一篇文章“跨皮质毛细血管网络作为长骨血液循环的主要支撑”解释了长骨的血管生成。在小鼠模型中，作者证明了有数百个贯穿皮质全层的跨皮质血管（TCV）起始于骨髓。他们意识到 TCV 与手术中观察到的人类胫骨和股骨骨骺骨膜床的出血血管相同。TCV 表达动脉或静脉标志物，并被提议作为骨骼血管生成的骨干，因为 80%的动脉血和 59%的静脉血通过它们分布。这一新证据挑战了先前文献中所述的“皮质毛细血管”的存在。我们对现有文献进行了回顾，以将该模型与早期研究进行比较。许多研究人员在猪、狗、兔和鼠等动物模型中进行了这项工作，解释了骨血管生成模型。在这些动物模型研究中，TCV 被鉴定为皮质毛细血管或皮质管的血管。在人类中，TCV 存在的研究很少。直到未来的研究收集到更多实质性证据，TCV 在人类皮质血管生成中的作用仍然不清楚。
