Hung Jinyi, Wang Xiaoying, Wang Xiaosha, Bi Yanchao
State Key Laboratory of Cognitive Neuroscience and Learning & IDG, McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China.
State Key Laboratory of Cognitive Neuroscience and Learning & IDG, McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China.
Neurosci Biobehav Rev. 2020 Aug;115:134-145. doi: 10.1016/j.neubiorev.2020.05.008. Epub 2020 May 26.
The anterior temporal lobe (ATL) is involved in a wide range of cognitive processes but its functional specialization remains unclear. In this review, we synthesize evidence from cytoarchitecture, anatomical and functional connectivity, and functional activation to elucidate how subregions in the ATL contribute to various cognitive processes. Two complementary meta-analyses were conducted. We first constructed a comprehensive functional preference profile for all subregions through large-scale neuroimaging meta-analysis, and then employed a coordinate-based activation likelihood estimation analysis to examine such functional preferences by input types. We identified two subregions in the dorsal aspect of the ATL (i.e., superior dorsal, inferior dorsal) and two other subregions (lateral, ventromedial) in the ventral aspect of the ATL, all have distinct anatomical and functional preferences. We proposed sensory, language, and socioemotion as the three dimensions that jointly capture the cognitive components cutting across the four ATL subregions: the superior dorsal ATL was associated with auditory sensory, language (phonological production aspects), and emotion; the inferior dorsal ATL with auditory sensory and language (phonological perception and production aspects); the lateral ATL with visual sensory, language (semantic and episodic aspects), and social processing; and the ventromedial ATL with visual sensory, episodic memory, and emotion. The various functions associated with the ATL can be clustered into subregions, which provides sourceful basis for testing hypothesis-driven cognitive framework.
颞叶前部（ATL）参与多种认知过程，但其功能特化仍不明确。在本综述中，我们综合来自细胞结构、解剖和功能连接以及功能激活的证据，以阐明ATL中的亚区域如何对各种认知过程做出贡献。我们进行了两项互补的荟萃分析。我们首先通过大规模神经影像学荟萃分析构建了所有亚区域的综合功能偏好概况，然后采用基于坐标的激活可能性估计分析，按输入类型检查此类功能偏好。我们在ATL背侧识别出两个亚区域（即上背侧、下背侧）以及ATL腹侧的另外两个亚区域（外侧、腹内侧），它们均具有独特的解剖和功能偏好。我们提出感觉、语言和社会情感作为共同涵盖四个ATL亚区域认知成分的三个维度：上背侧ATL与听觉感觉、语言（语音产生方面）和情感相关；下背侧ATL与听觉感觉和语言（语音感知和产生方面）相关；外侧ATL与视觉感觉、语言（语义和情景方面）以及社会加工相关；腹内侧ATL与视觉感觉、情景记忆和情感相关。与ATL相关的各种功能可聚类到亚区域中，这为检验假设驱动的认知框架提供了丰富的基础。
