Division of Cardiology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: https://twitter.com/ankeetbhatt.
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
J Am Coll Cardiol. 2020 Jul 21;76(3):280-288. doi: 10.1016/j.jacc.2020.05.038. Epub 2020 May 26.
Although patients with cardiovascular disease face excess risks of severe illness with coronavirus disease-2019 (COVID-19), there may be indirect consequences of the pandemic on this high-risk patient segment.
This study sought to examine longitudinal trends in hospitalizations for acute cardiovascular conditions across a tertiary care health system.
Acute cardiovascular hospitalizations were tracked between January 1, 2019, and March 31, 2020. Daily hospitalization rates were estimated using negative binomial models. Temporal trends in hospitalization rates were compared across the first 3 months of 2020, with the first 3 months of 2019 as a reference.
From January 1, 2019, to March 31, 2020, 6,083 patients experienced 7,187 hospitalizations for primary acute cardiovascular reasons. There were 43.4% (95% confidence interval [CI]: 27.4% to 56.0%) fewer estimated daily hospitalizations in March 2020 compared with March 2019 (p < 0.001). The daily rate of hospitalizations did not change throughout 2019 (-0.01% per day [95% CI: -0.04% to +0.02%]; p = 0.50), January 2020 (-0.5% per day [95% CI: -1.6% to +0.5%]; p = 0.31), or February 2020 (+0.7% per day [95% CI: -0.6% to +2.0%]; p = 0.27). There was significant daily decline in hospitalizations in March 2020 (-5.9% per day [95% CI: -7.6% to -4.3%]; p < 0.001). Length of stay was shorter (4.8 days [25th to 75th percentiles: 2.4 to 8.3 days] vs. 6.0 days [25th to 75th percentiles: 3.1 to 9.6 days]; p = 0.003) and in-hospital mortality was not significantly different (6.2% vs. 4.4%; p = 0.30) in March 2020 compared with March 2019.
During the first phase of the COVID-19 pandemic, there was a marked decline in acute cardiovascular hospitalizations, and patients who were admitted had shorter lengths of stay. These data substantiate concerns that acute care of cardiovascular conditions may be delayed, deferred, or abbreviated during the COVID-19 pandemic.
尽管心血管疾病患者面临着与 2019 年冠状病毒病(COVID-19)相关的严重疾病的风险增加,但大流行可能会对这一高危患者群体产生间接影响。
本研究旨在研究一个三级保健系统中急性心血管疾病住院治疗的纵向趋势。
2019 年 1 月 1 日至 2020 年 3 月 31 日期间,跟踪急性心血管疾病住院治疗情况。使用负二项式模型估算每日住院率。将 2020 年 3 月与 2019 年 3 月的前 3 个月进行比较,以评估住院率的时间趋势。
2019 年 1 月 1 日至 2020 年 3 月 31 日期间,6083 名患者因原发性急性心血管疾病住院治疗 7187 次。与 2019 年 3 月相比,2020 年 3 月的估计每日住院人数减少了 43.4%(95%置信区间[CI]:27.4%至 56.0%;p<0.001)。2019 年全年(每日下降 0.01%;95%CI:-0.04%至 0.02%;p=0.50)、2020 年 1 月(每日下降 0.5%;95%CI:-1.6%至 0.5%;p=0.31)或 2020 年 2 月(每日上升 0.7%;95%CI:-0.6%至 2.0%;p=0.27)的每日住院率均无变化。2020 年 3 月的住院人数呈显著下降趋势(每日下降 5.9%;95%CI:-7.6%至-4.3%;p<0.001)。2020 年 3 月的住院时间更短(25%至 75%分位数:2.4 至 8.3 天;6.0 天;25%至 75%分位数:3.1 至 9.6 天;p=0.003),院内死亡率无显著差异(6.2%比 4.4%;p=0.30)。
在 COVID-19 大流行的第一阶段,急性心血管疾病住院治疗明显减少,住院患者的住院时间缩短。这些数据证实了人们的担忧,即 COVID-19 大流行期间,心血管疾病的急性护理可能会被延迟、推迟或缩短。