肌肉病的认知缺陷。
Cognitive Deficits in Myopathies.
机构信息
Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, 41110 Larissa, Greece.
Public Health Laboratories, Hellenic Pasteur Institute, 11521 Athens, Greece.
出版信息
Int J Mol Sci. 2020 May 27;21(11):3795. doi: 10.3390/ijms21113795.
Myopathies represent a wide spectrum of heterogeneous diseases mainly characterized by the abnormal structure or functioning of skeletal muscle. The current paper provides a comprehensive overview of cognitive deficits observed in various myopathies by consulting the main libraries (Pubmed, Scopus and Google Scholar). This review focuses on the causal classification of myopathies and concomitant cognitive deficits. In most studies, cognitive deficits have been found after clinical observations while lesions were also present in brain imaging. Most studies refer to hereditary myopathies, mainly Duchenne muscular dystrophy (DMD), and myotonic dystrophies (MDs); therefore, most of the overview will focus on these subtypes of myopathies. Most recent bibliographical sources have been preferred.
肌病是一大类异质性疾病，主要表现为骨骼肌结构或功能异常。本文通过查阅主要文献库（PubMed、Scopus 和 Google Scholar），综述了各种肌病中观察到的认知缺陷。本综述重点讨论了肌病和伴随的认知缺陷的因果分类。在大多数研究中，在临床观察到认知缺陷后，在脑影像学中也发现了病变。大多数研究涉及遗传性肌病，主要是杜氏肌营养不良症（DMD）和强直性肌营养不良症（MDs）；因此，本综述将主要关注这些肌病亚型。本综述优先采用了最新的文献资料。
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