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糙皮侧耳诱导斜纹夜蛾产生氧化应激和免疫抑制活性。

Schizophyllum commune induced oxidative stress and immunosuppressive activity in Spodoptera litura.

机构信息

Department of Zoology, Guru Nanak Dev University, Amritsar, Punjab, India.

Department of Microbiology, Guru Nanak Dev University, Amritsar, Punjab, India.

出版信息

BMC Microbiol. 2020 May 29;20(1):139. doi: 10.1186/s12866-020-01831-6.

DOI:10.1186/s12866-020-01831-6
PMID:32471364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7260734/
Abstract

BACKGROUND

In the last few decades, considerable attention has been paid to fungal endophytes as biocontrol agents, however little is known about their mode of action. This study aimed to investigate the toxic effects of an endophytic fungus Schizophyllum commune by analyzing activities of antioxidant and detoxifying enzymes as well as morphology of haemocytes using Spodoptera litura as a model.

RESULTS

Ethyl acetate extract of S. commune was fed to the larvae of S. litura using the artificial diet having 276.54 μg/ml (LC of fungus) concentration for different time durations. Exposed groups revealed significant (p ≤ 0.05) increase in the activities of various enzymes viz. Catalase, Ascorbate peroxidase, Superoxide dismutase, Glutathione-S-Transferase. Furthermore, haemocytes showed various deformities like breakage in the cell membrane, cytoplasmic leakage and appearance of strumae in the treated larvae. A drastic reduction in the percentage of normal haemocytes was recorded in the treated groups with respect to control.

CONCLUSION

The study provides important information regarding the oxidative stress causing and immunosuppressant potential of S. commune against S. litura and its considerable potential for incorporation in pest management programs.

摘要

背景

在过去的几十年中，人们对真菌内生菌作为生物防治剂给予了相当多的关注，但对其作用模式知之甚少。本研究旨在通过分析抗氧化和解毒酶的活性以及血细胞形态，以斜纹夜蛾为模型，研究内生真菌栓菌的毒性作用。

结果

采用含有 276.54μg/ml（真菌 LC）浓度的人工饲料，用栓菌的乙酸乙酯提取物喂养斜纹夜蛾幼虫不同时间。暴露组的各种酶（如过氧化氢酶、抗坏血酸过氧化物酶、超氧化物歧化酶、谷胱甘肽 S-转移酶）的活性显著增加（p≤0.05）。处理组的血细胞出现各种变形，如细胞膜破裂、细胞质渗漏和出现皱襞。与对照组相比，处理组正常血细胞的百分比明显减少。

结论

本研究提供了关于栓菌对斜纹夜蛾造成氧化应激和免疫抑制的重要信息，以及其在害虫管理计划中应用的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/32423fdade64/12866_2020_1831_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/339f10516ab8/12866_2020_1831_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/e5e3bfd51e2a/12866_2020_1831_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/1ef994b835ae/12866_2020_1831_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/4138ad039388/12866_2020_1831_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/32423fdade64/12866_2020_1831_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/339f10516ab8/12866_2020_1831_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/e5e3bfd51e2a/12866_2020_1831_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/1ef994b835ae/12866_2020_1831_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/4138ad039388/12866_2020_1831_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a443/7260734/32423fdade64/12866_2020_1831_Fig5_HTML.jpg

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