每日两次的低频重复经颅磁刺激（LF-rTMS）是难治性强迫症的可行治疗选择吗？一项开放标签可行性研究的结果。
Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study.
作者信息
Tandt Hannelore L N, Van de Velde Nele, De Witte Sara, Audenaert Kurt, Baeken Chris, Lemmens Gilbert M D
机构信息
Department of Psychiatry, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Department of Head and Skin-Psychiatry and Medical Psychology, Ghent University, Ghent, Belgium.
出版信息
Eur Arch Psychiatry Clin Neurosci. 2021 Feb;271(1):211-214. doi: 10.1007/s00406-020-01142-x. Epub 2020 May 29.
Several reports point to the beneficial effects of repetitive transcranial magnetic stimulation (rTMS) in the treatment of resistant obsessive-compulsive disorder (OCD). This study aimed to evaluate the safety and efficacy of rTMS targeting the dmPFC in the treatment of treatment-resistant OCD patients. Twelve patients received 20 sessions of low-frequency (LF) rTMS (1 Hz, 1200 pulses) in a twice daily protocol during 10 weekdays. Y-BOCS and IDS scores modestly but significantly decreased after treatment and at follow-up and HADS anxiety improved at follow-up. LF rTMS may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD and was a safe and well-tolerated treatment.
多项报告指出重复经颅磁刺激（rTMS）在治疗难治性强迫症（OCD）方面具有有益效果。本研究旨在评估针对背内侧前额叶皮质（dmPFC）进行rTMS治疗难治性OCD患者的安全性和有效性。12名患者在10个工作日内接受了每日两次、每次20次的低频（LF）rTMS（1赫兹，1200个脉冲）治疗。治疗后及随访时，耶鲁布朗强迫症量表（Y-BOCS）和抑郁症状量表（IDS）评分略有但显著下降，且随访时医院焦虑抑郁量表（HADS）焦虑评分有所改善。低频rTMS可能改善难治性OCD患者的OCD、焦虑和抑郁症状，且是一种安全且耐受性良好的治疗方法。
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