在发育正常的成年人中，左侧而非右侧初级视觉区的灰质厚度与自闭症特征相关。
Grey-Matter Thickness of the Left But Not the Right Primary Visual Area Correlates with Autism Traits in Typically Developing Adults.
作者信息
Yildiz Gizem Y, Vilsten Julian S, Millard Amy Siobhan, Chouinard Philippe A
机构信息
Department of Psychology and Counselling, School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.
出版信息
J Autism Dev Disord. 2021 Feb;51(2):405-417. doi: 10.1007/s10803-020-04553-w.
We examined whether functional and structural variability in the primary visual area (V1) correlated with autism traits. Twenty-nine participants (16 males; M = 26.4 years, SD = 4.0 years) completed the autism-spectrum quotient (AQ) questionnaire prior to a magnetic resonance imaging session. The total AQ scores was used to assess the degree of self-reported autism traits. The average functional activation in V1 to visual stimulation and its average grey-matter thickness were calculated. There were no correlations between functional activation in V1 and autism traits. Conversely, grey-matter thickness of the left but not the right V1 correlated with autism traits. We conclude that structural changes in the left V1 could be a marker for the presence of autism traits.
我们研究了初级视觉皮层（V1）的功能和结构变异性是否与自闭症特征相关。29名参与者（16名男性；平均年龄M = 26.4岁，标准差SD = 4.0岁）在进行磁共振成像检查前完成了自闭症谱系商数（AQ）问卷。总AQ得分用于评估自我报告的自闭症特征程度。计算了V1对视觉刺激的平均功能激活及其平均灰质厚度。V1的功能激活与自闭症特征之间没有相关性。相反，左侧而非右侧V1的灰质厚度与自闭症特征相关。我们得出结论，左侧V1的结构变化可能是自闭症特征存在的一个标志。
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