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孟加拉国用于移植的人体骨骼和羊膜库:国际原子能机构(IAEA)项目的影响。

Human bone and amniotic membrane banking in Bangladesh for grafting: the impact of the international atomic energy agency (IAEA) programme.

作者信息

Zahid Hasan M, Rahman Md Shaifur, Diba Farzana, Hossain Md Liakat, Akhtar Naznin, Siddika Ayesha, Adnan Md Hasib, Jorge Morales Pedraza, Asaduzzaman Sikder M

机构信息

Institute of Tissue Banking and Biomaterial Research, Atomic Energy Research Establishment, Dhaka, 1349, Bangladesh.

Institute for Stem Cell Research and Regenerative Medicine, University Hospital Düsseldorf, Heinrich Heine University, 40225, Düsseldorf, Germany.

出版信息

Cell Tissue Bank. 2020 Sep;21(3):523-533. doi: 10.1007/s10561-020-09839-y. Epub 2020 May 29.

Abstract

The idea of establishing a human tissue bank in Bangladesh was started in 1985. However, in 2003, with the active cooperation of international atomic energy agency (IAEA) and Bangladesh Atomic Energy Commission, a tissue bank laboratory was upgraded as a unit for tissue banking and research. Due to increasing demand of allograft, this unit was transformed as an independent institute "Institute of Tissue Banking and Biomaterial Research (ITBBR)" in 2016. This is the only human tissue bank in Bangladesh, which processes human bone and amniotic membrane to provide safe and cost-effective allografts for transplantation. Importantly, banking of human cranial bone as autograft has also started at ITBBR. These processed grafts are sterilized using gamma radiation according to the IAEA Code of Practice for the radiation sterilization of tissues allografts. The amount of grafts produced by the ITBBR from 2007 to 2018 were 120,800 cc of bone chips, 45,420 cm of amniotic membranes, 277 vials of de-mineralized bone granules (DMB), 95 pieces of massive bones, and 134 pieces of cranial bones. Overall, 112,748 cc of bone chips, 40,339 cm of amniotic membranes, 174 vials of DMB, 44 pieces of massive bones, and 64 pieces of cranial bones were transplanted successfully. Nevertheless, to cope up with the modern advanced concepts of cell and tissue banking for therapeutic purpose, ITBBR is working to set up facilities for skin banking, stem cells banking including amniotic and cord blood derived stem cells and scaffold designing. To ensure the quality, safety, ethical and regulatory issues are sustainable in cell and tissue banking practices, ITBBR always works with the Government of Bangladesh for enhancing the national tissue transplantation programme within the contemporary facilities.

摘要

在孟加拉国建立人体组织库的想法始于1985年。然而,2003年,在国际原子能机构(IAEA)和孟加拉国原子能委员会的积极合作下,一个组织库实验室升级为组织库与研究单位。由于同种异体移植需求不断增加,该单位于2016年转变为独立机构“组织库与生物材料研究所(ITBBR)”。这是孟加拉国唯一的人体组织库,负责处理人体骨骼和羊膜,以提供安全且经济高效的同种异体移植用于移植。重要的是,ITBBR也已开始将人体颅骨作为自体移植物进行储存。这些经过处理的移植物根据国际原子能机构关于组织同种异体移植辐射灭菌的操作规范,使用伽马射线进行灭菌。ITBBR在2007年至2018年期间生产的移植物数量为:120,800立方厘米骨屑、45,420厘米羊膜、277瓶脱矿骨颗粒(DMB)、95块大块骨骼和134块颅骨。总体而言,成功移植了112,748立方厘米骨屑、40,339厘米羊膜、174瓶DMB、44块大块骨骼和64块颅骨。尽管如此,为了应对用于治疗目的的细胞和组织库的现代先进理念,ITBBR正在努力建立皮肤库、干细胞库(包括羊膜和脐带血来源的干细胞)以及支架设计设施。为确保细胞和组织库实践中的质量、安全、伦理和监管问题可持续,ITBBR始终与孟加拉国政府合作,在当代设施范围内加强国家组织移植计划。

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