Höffken K, Seeber S, Gallmeier W M, Bruntsch U, Hossfeld D K, Schmidt C G
Chirurg. 1977 Apr;48(4):274-9.
In several primary malignant tumors significant improvement of formely bad prognosis has been achieved by the introduction of new cytostatic compounds and the study of new cytostatic combination regimens. Adjuvant chemotherapy in osteosarcoma and Ewing's sarcoma led to remarkable increase in survival rates. Leaning on natural history and on remission rates reached by cytostatic treatment in metastasizing stages of disease, proposals for adjuvant chemotherapy are made and chemotherapy regimen appliable on out-patient basis is described.
在几种原发性恶性肿瘤中，通过引入新的细胞毒性化合物以及研究新的细胞毒性联合治疗方案，显著改善了以往较差的预后。骨肉瘤和尤因肉瘤的辅助化疗使生存率显著提高。基于疾病转移阶段的自然病史和细胞毒性治疗所达到的缓解率，提出了辅助化疗的建议，并描述了适用于门诊治疗的化疗方案。
