Department of Emergency, West China Second University Hospital and Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Sichuan University, Chengdu, China.
Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, China.
Immunol Lett. 2020 Aug;224:14-20. doi: 10.1016/j.imlet.2020.05.001. Epub 2020 May 28.
Under lymphopenic conditions, the rapid spontaneous proliferation produces cells that robustly differentiate into effector memory T (T) cells, and the aberrant expansion is preferentially driven by self-antigens. The pool size of effector memory T-cell is governed by a complex homeostatic balance between proliferation and death. Perp is a critical effector involved in the p53-dependent apoptotic pathway and widely expressed in mammalian tissues. We have previously shown that Perp has a prominent role in activation-induced cell death of peripheral Th17 cells. Here, we show that Peripheral PerpCD4 T cells outcompete wild type T cells for access to splenic niches in vivo. The skewing of the Perp T cells compartment was not the result of a difference in lymphopenia-induced proliferation, but the resistance to apoptosis, particularly after anti-Fas treatment. Data presented in this work indicate that Perp mediates the persistence of CD4 T cells in irradiation-induced lymphopenic settings.
在淋巴缺乏的情况下，快速的自发增殖产生了能够强有力地分化为效应记忆 T（T）细胞的细胞，这种异常扩增主要是由自身抗原驱动的。效应记忆 T 细胞的池大小由增殖和死亡之间的复杂动态平衡来控制。Perp 是一种关键的效应因子，参与 p53 依赖性凋亡途径，广泛表达于哺乳动物组织中。我们之前已经表明，Perp 在周围 Th17 细胞的激活诱导细胞死亡中起着重要作用。在这里，我们表明外周 PerpCD4 T 细胞在体内竞争进入脾脏小生境的能力超过野生型 T 细胞。Perp T 细胞区室的倾斜不是由于淋巴减少诱导的增殖差异，而是对凋亡的抵抗力，特别是在抗 Fas 治疗后。本工作中提供的数据表明，Perp 介导了 CD4 T 细胞在照射诱导的淋巴缺乏环境中的持续存在。
