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Bruton's tyrosine kinase in systemic lupus erythematosus.

作者信息

Liao Hsien-Tzung, Tung Hsiang-Yuen, Tsai Chang-Youh, Chiang Bor-Luen, Yu Chia-Li

机构信息

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

出版信息

Joint Bone Spine. 2020 Dec;87(6):670-672. doi: 10.1016/j.jbspin.2020.05.004. Epub 2020 May 27.

DOI:10.1016/j.jbspin.2020.05.004
PMID:32473417
Abstract
摘要

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Bruton's tyrosine kinase in systemic lupus erythematosus.布鲁顿酪氨酸激酶与系统性红斑狼疮
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Targeting Bruton's tyrosine kinase (BTK) as a signaling pathway in immune-mediated diseases: from molecular mechanisms to leading treatments.靶向布鲁顿酪氨酸激酶（BTK）作为免疫介导性疾病的信号通路：从分子机制到主要治疗方法。
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Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus.高选择性布鲁顿酪氨酸激酶抑制剂可减轻狼疮小鼠的皮肤和脑部疾病。
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Increased expression of Bruton's tyrosine kinase in peripheral blood is associated with lupus nephritis.外周血中布鲁顿酪氨酸激酶表达增加与狼疮肾炎有关。
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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.JNJ-64264681的发现：一种强效且选择性的布鲁顿酪氨酸激酶共价抑制剂。
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BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis.BTK 抑制可改善自发性狼疮肾炎的肾脏疾病。
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Bruton's tyrosine kinase inhibition-An emerging therapeutic strategy in immune-mediated dermatological conditions.布鲁顿酪氨酸激酶抑制 - 一种新兴的免疫介导性皮肤病治疗策略。
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The potential of Bruton's tyrosine kinase (BTK) inhibitors in the pharmacotherapeutic management of immune and dermatological disease.布鲁顿酪氨酸激酶（BTK）抑制剂在免疫和皮肤疾病药物治疗管理中的潜力。
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Bruton's Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures.布鲁顿酪氨酸激酶（BTK）抑制剂与自身免疫性疾病：解析 BTK 抑制剂的特异性特征及近期临床试验的成败。
Front Immunol. 2021 Nov 3;12:662223. doi: 10.3389/fimmu.2021.662223. eCollection 2021.

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Front Dent Med. 2023 May 16;4:1168645. doi: 10.3389/fdmed.2023.1168645. eCollection 2023.
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BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms and clinical studies.BTK 抑制剂在血液系统恶性肿瘤和炎症性疾病治疗中的作用机制及临床研究。
J Hematol Oncol. 2022 Oct 1;15(1):138. doi: 10.1186/s13045-022-01353-w.
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Changes in the BTK/NF-κB signaling pathway and related cytokines in different stages of neuromyelitis optica spectrum disorders.
视神经脊髓炎谱系疾病不同阶段 BTK/NF-κB 信号通路及相关细胞因子的变化。
Eur J Med Res. 2022 Jun 21;27(1):96. doi: 10.1186/s40001-022-00723-x.