Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Institute of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
BMC Cancer. 2020 May 30;20(1):489. doi: 10.1186/s12885-020-06976-1.
The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among patients with smoldering MM (SMM).
Changes in various components of metabolic syndrome were investigated during the follow-up of patients with either MM or SMM compared to healthy controls. The data of 153 patients (105 with MM and 48 with SMM) and 138 controls were accessed from our medical center's records between 2008 and 2015. We analyzed the patients' data at diagnosis (baseline) and after 1, 3, and 5 years of follow-up.
Patients with SMM had a significantly higher prevalence of diabetes, hypertension, and dyslipidemia at baseline compared to controls. A multivariate Cox regression analysis revealed a higher risk to develop dyslipidemia after 1, 3, and 5 years of follow-up among the SMM patients. The MM patients had a higher risk to develop diabetes after 1 year, hypertension after 5 years, and dyslipidemia after 1, 3, and 5 years of follow-up.
These data demonstrate that patients with SMM and those with MM are more prone to develop various components of metabolic syndrome, and they stress the importance of following-up metabolic syndrome components in both groups of patients.
已知患有多发性骨髓瘤（MM）的患者中糖尿病和高血压（两者均为代谢综合征的组成部分）的患病率增加，但患有冒烟型多发性骨髓瘤（SMM）的患者中代谢综合征的患病率仍不确定。
我们比较了 MM 或 SMM 患者与健康对照者在随访期间代谢综合征各成分的变化。我们从 2008 年至 2015 年我们医疗中心的记录中获取了 153 例患者（105 例 MM 和 48 例 SMM）和 138 例对照者的数据。我们在诊断（基线）时以及随访 1、3 和 5 年后分析了患者的数据。
SMM 患者在基线时与对照组相比，糖尿病、高血压和血脂异常的患病率明显更高。多变量 Cox 回归分析显示，SMM 患者在随访 1、3 和 5 年后发生血脂异常的风险更高。MM 患者在随访 1 年后发生糖尿病、5 年后发生高血压以及在 1、3 和 5 年后发生血脂异常的风险更高。
这些数据表明，SMM 患者和 MM 患者更易发生代谢综合征的各种成分，并且强调了在这两组患者中监测代谢综合征成分的重要性。
