Thomas P R, Dormandy J A
Department of Surgery, St. George's Hospital, London.
Phlebologie. 1988 Nov-Dec;41(4):771-6.
The cause of venous ulceration remains unclear but recent evidence suggests that white cell trapping may play a significant role. In this study venous blood taken from the dependent leg of 15 normal subjects was compared to samples taken from a similar number of patients with deep venous insufficiency. About 25 p. cent fewer white cells and platelets left the dependent foot of the patients with venous hypertension. When the foot was elevated there was a significant washout of white cells but not platelets suggesting platelet consumption within the microcirculation of the dependent foot. In 8 of the patients these changes were reversed by external compression.
静脉溃疡的病因尚不清楚，但最近的证据表明白细胞滞留可能起重要作用。在本研究中，将15名正常受试者患侧下肢采集的静脉血与相同数量的深静脉功能不全患者采集的样本进行了比较。静脉高压患者患侧足部流出的白细胞和血小板比正常人少约25%。当足部抬高时，白细胞显著减少，但血小板未减少，提示患侧足部微循环内存在血小板消耗。8例患者经外部加压后这些变化得以逆转。
