School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
Psychiatry Res. 2020 Aug;290:113019. doi: 10.1016/j.psychres.2020.113019. Epub 2020 May 17.
Disorganized communication among large-scale brain networks, especially in the salience network, default mode network and central executive network, have been consistently reported in schizophrenia (SZ) patients. However, abnormal patterns of the effective connectivity and abnormalities in the white matter of these networks remains unclear in patients with SZ. Fifty-six SZ patients and fifty-five healthy controls were enrolled in the present study and underwent resting state functional magnetic resonance and diffusion tensor imaging. Twelve main nodes within the triple networks were defined by independent components analysis. Effective connectivity between these main nodes was computed using Granger causality analysis. Voxel-based analysis of the diffusion tensor imaging data was conducted to explore white matter changes. The SZ patients showed abnormal effective connectivity between the anterior cingulate cortex and the dorsolateral prefrontal cortex. The abnormal white matter showed decreased fractional anisotropy localized in the bilateral anterior corona radiate and left superior long fasciculus in patients with SZ. These findings shed light on the importance of the triple network in the pathogenesis of SZ, which may facilitate the understanding of SZ.
在精神分裂症（SZ）患者中，一直有报道称，大规模脑网络之间的沟通不连贯，尤其是在突显网络、默认模式网络和中央执行网络中。然而，SZ 患者这些网络的有效连通性的异常模式和白质异常仍然不清楚。本研究纳入了 56 名 SZ 患者和 55 名健康对照者，并进行了静息态功能磁共振和弥散张量成像。通过独立成分分析，定义了三网络中的 12 个主要节点。使用格兰杰因果分析计算了这些主要节点之间的有效连通性。对弥散张量成像数据进行体素分析，以探讨白质变化。SZ 患者在前扣带皮层和背外侧前额叶皮层之间表现出异常的有效连通性。异常的白质表现为 SZ 患者双侧前冠状辐射和左侧上长束的分数各向异性降低。这些发现揭示了三网络在 SZ 发病机制中的重要性，这可能有助于理解 SZ。
