WISER Neuromodulation Program, Department of Psychiatry, National Institute of Mental Health And Neurosciences, Bengaluru, India.
WISER Neuromodulation Program, Department of Psychiatry, National Institute of Mental Health And Neurosciences, Bengaluru, India.
Psychiatry Res. 2020 Aug;290:113106. doi: 10.1016/j.psychres.2020.113106. Epub 2020 May 23.
The utility of non-invasive brain stimulation techniques to alleviate resistant delusions in schizophrenia is an under-researched area. In this study, we report the effectiveness of alpha transcranial alternating current stimulation (tACS) targeting the medial prefrontal cortex in ameliorating persistent delusions. Twelve Schizophrenia patients (N=12) with persistent delusions received add-on treatment with a twice-daily 20-minutes session of 10-Hz tACS. Significant reduction in severity of delusion was noted after 5th day (z=2.67, p<0.01, n=12) with further improvement after 10th day (z=2.52, p=0.01, n=9) of stimulation. Add-on treatment with 10-Hz tACS is a potential therapeutic option for treatment-resistant delusions, which requires further systematic research.
经颅交流电刺激（tACS）对改善持续性妄想的效果研究
经颅交流电刺激（tACS）技术应用于缓解精神分裂症患者的难治性妄想的效用是一个研究不足的领域。在本研究中，我们报告了经颅交流电刺激（tACS）针对内侧前额叶的有效性，可改善持续性妄想。12 名患有持续性妄想的精神分裂症患者（N=12）接受了每日两次、每次 20 分钟、频率为 10Hz 的 tACS 附加治疗。在刺激的第 5 天（z=2.67，p<0.01，n=12）和第 10 天（z=2.52，p=0.01，n=9）后，妄想的严重程度显著降低。10Hz tACS 的附加治疗可能是一种治疗难治性妄想的治疗选择，但需要进一步的系统研究。
