经颅交流电刺激对多任务处理性能的参数影响。
Parametric effects of transcranial alternating current stimulation on multitasking performance.
机构信息
Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Neuroscape, University of California, San Francisco, San Francisco, CA, USA.
Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Neuroscape, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Brain Stimul. 2019 Jan-Feb;12(1):73-83. doi: 10.1016/j.brs.2018.10.010. Epub 2018 Oct 23.
BACKGROUND
We have previously demonstrated that transcranial alternating current stimulation (tACS) can generate positive effects on multitasking performance and associated neurophysiological measures when it is applied with anti-phase theta band stimulation across bilateral prefrontal cortex (PFC) and a short (1-min) inter-session interval (ISI). However, it is unclear how altering the phase of stimulation and the duration of the ISI might impact positive tACS effects. Here, we investigated the role of tACS parameters in engendering performance improvements by manipulating these two stimulation parameters (i.e. phase and ISI) in two experiments.
METHODS
Repetitive sessions of bilateral PFC theta-tACS were applied with in-phase stimulation + 1-min ISI (experiment 1) and anti-phase stimulation + 5-min ISI (experiment 2) while participants were engaged in a multitasking challenge accompanied by electroencephalography (EEG) data collection.
RESULTS
Compared to the control group, in-phase stimulation + 1-min ISI showed an enhancement of multitasking performance coupled with a modulation of posterior alpha (8-12 Hz) and beta (13-30 Hz) activities. However, repetitive sessions of anti-phase tACS + 5-min ISI did not generate significant enhancement in multitasking performance, nor changes in neural oscillatory activities compared to the control group.
CONCLUSION
The results revealed that the previous reported positive tACS effects on multitasking performance are not affected by manipulating the phase of current polarity. Yet, changing the ISI of the stimulation protocol eliminated the previous observed performance improvements. Taken together, these results stress the importance of stimulation protocol for generating positive tACS effects on cognitive function and neural oscillations.
背景
我们之前的研究表明，当经颅交流电刺激（tACS）以反相θ频段刺激双侧前额叶皮质（PFC），并采用短（1 分钟）的会话间隔（ISI）时，它可以对多任务表现和相关的神经生理测量产生积极影响。然而，目前尚不清楚改变刺激的相位和 ISI 的持续时间如何影响正 tACS 效应。在这里，我们通过在两个实验中操纵这两个刺激参数（即相位和 ISI），研究了 tACS 参数在产生性能提升中的作用。
方法
在参与者进行多任务挑战的同时，进行双侧 PFCθ-tACS 的重复会话，采用同相刺激+1 分钟 ISI（实验 1）和反相刺激+5 分钟 ISI（实验 2），同时采集脑电图（EEG）数据。
结果
与对照组相比，同相刺激+1 分钟 ISI 显示出多任务表现的增强，伴随着后 alpha（8-12Hz）和 beta（13-30Hz）活动的调制。然而，与对照组相比，反相 tACS 的重复会话+5 分钟 ISI 并没有显著提高多任务表现，也没有改变神经振荡活动。
结论
结果表明，以前关于 tACS 对多任务表现的积极影响不受电流极性相位的影响。然而，改变刺激方案的 ISI 消除了以前观察到的性能改善。综上所述，这些结果强调了刺激方案对产生正 tACS 效应和神经振荡的重要性。
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