Department of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Department of Cell Biology, Institute of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Bone. 2020 Aug;137:115458. doi: 10.1016/j.bone.2020.115458. Epub 2020 May 28.
The development of osteoblasts, a bone-forming cell population, occurs in conjunction with development of the skeleton, which creates our physical framework and shapes the body. In the past two decades, genetic studies have uncovered the molecular framework of this process-namely, transcriptional regulators and signaling pathways coordinate the cell fate determination and differentiation of osteoblasts in a spatial and temporal manner. Recently emerging genome-wide studies provide additional layers of understanding of the gene regulatory landscape during osteoblast differentiation, allowing us to gain novel insight into the modes of action of the key regulators, functional interaction among the regulator-bound enhancers, epigenetic regulations, and the complex nature of regulatory inputs. In this review, we summarize current understanding of the transcriptional regulation in osteoblasts, in terms of the gene regulatory landscape.
成骨细胞（一种骨形成细胞群体）的发育与骨骼的发育同时发生，骨骼为我们提供了身体框架并塑造了我们的身体。在过去的二十年中，遗传研究揭示了这一过程的分子框架——即转录调节剂和信号通路以时空方式协调成骨细胞的细胞命运决定和分化。最近出现的全基因组研究为成骨细胞分化过程中的基因调控景观提供了更多的理解层次，使我们能够深入了解关键调节剂的作用模式、调节剂结合增强子之间的功能相互作用、表观遗传调控以及调控输入的复杂性质。在这篇综述中，我们根据基因调控景观总结了目前对成骨细胞转录调控的理解。
