School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.
Department of Geography and Environmental Studies, University of Haifa, Haifa, Israel.
Environ Res. 2020 Aug;187:109678. doi: 10.1016/j.envres.2020.109678. Epub 2020 May 20.
To examine whether high ambient temperature and diurnal temperature range during the summer are associated with risk of stroke/transient ischemic attack (TIA).
A time-stratified case-crossover study design was conducted. The study sample comprised all individuals aged ≥50 years who had a stroke/TIA reported to the Israeli National Stroke Registry between 2014 and 2016 during the summer season. Daily temperature data were retrieved from the Israel Meteorological Service. Conditional logistic regression models were used with relative humidity and air pollution as covariates.
The sample included 15,123 individuals who had a stroke/TIA during the summer season (mean age 73 ± 12 years; 54% males). High ambient temperature was associated with stroke/TIA risk starting from the day before the stroke event, and increasing in strength over a six-day lag (OR = 1.10 95%CI 1.09-1.12). Moreover, a larger diurnal temperature range prior to stroke/TIA occurrence was associated with decreased stroke/TIA risk (OR = 0.96 95%CI 0.95-0.97 for a six-day lag).
High ambient temperature may be linked to increased risk of cerebrovascular events in subsequent days. However, relief from the heat during the night may attenuate this risk.
研究夏季环境温度和日温差升高是否与中风/短暂性脑缺血发作（TIA）风险相关。
采用时间分层病例交叉研究设计。研究样本包括 2014 年至 2016 年夏季期间向以色列国家中风登记处报告的所有年龄≥50 岁的中风/TIA 患者。每日温度数据从以色列气象局获取。使用相对湿度和空气污染作为协变量进行条件逻辑回归模型分析。
本研究纳入了 15123 名夏季发生中风/TIA 的患者（平均年龄 73±12 岁，54%为男性）。环境高温与中风/TIA 风险相关，发病前一天开始增加，并在 6 天的滞后时间内逐渐增强（OR=1.10，95%CI 1.09-1.12）。此外，中风/TIA 发生前较大的日温差与中风/TIA 风险降低相关（6 天滞后 OR=0.96，95%CI 0.95-0.97）。
环境高温可能与随后几天的脑血管事件风险增加有关。然而，夜间散热可能会减轻这种风险。
