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三代人中心律紊乱的遗传情况(家族病史)

[The inheritance of disorders of heart rhythm in 3 generations (a family history)].

作者信息

Fomina I G, Logunova L V, Morgunov N B

出版信息

Ter Arkh. 1988;60(12):131-2.

PMID:3247646
Abstract

The paper is concerned with the description of a family where father suffered from right bundle-branch block, his daughter--from Wolff-Parkinson-White syndrome (type B) with attacks of supraventricular paroxysmal tachycardia, one granddaughter--from Clerc-Lévy-Cristesco syndrome with attacks of sinus tachycardia, the two other granddaughters had a short P-R interval. Medicogenetic investigation revealed not only the inheritance of myocardial conduction changes of autosomal dominant type but also of syndromes characterizing primary dysplasia of connective tissue in 3 generations.

摘要

该论文描述了这样一个家族

父亲患有右束支传导阻滞,其女儿患有B型预激综合征并伴有室上性阵发性心动过速发作,一个孙女患有克莱尔-列维-克里斯泰斯科综合征并伴有窦性心动过速发作,另外两个孙女的P-R间期缩短。医学遗传学研究不仅揭示了常染色体显性类型的心肌传导变化的遗传情况,还发现了三代人中结缔组织原发性发育异常所特有的综合征的遗传情况。

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