Kemal Can Tertemiz, Aylin Ozgen Alpaydin, Volkan Karacam, Seda Mersin, Recep Bekis, Can Sevinc
Pulmonary Diseases, Dokuz Eylul University Medical Faculty, Izmir, Turkey.
Thoracic Surgery, Dokuz Eylul University Medical Faculty, Izmir, Turkey.
Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(3):242-250. doi: 10.36141/svdld.v34i3.5299. Epub 2020 Mar 9.
We aimed to reveal the correlation of NLR rate, RDW and MPV values and with the findings of PET/CT regarding the prediction of disease progression and the clinical characteristics. The treatment naive sarcoidosis cases, of whose PET/CT have been taken due to mediastinal lymphadenopathy of whose diagnosis have been confirmed by biopsy, were included in the study. Hematological parameters, clinical, radiological and PET/CT findings are evaluated. 40 sarcoidosis and 40 healthy control cases were included in the study. NLR, RDW, MPV and the sedimentation values in the sarcoidosis group were determined statistically significantly higher. In patients having parenchymal involvement in PET/CT, the values of FVC%, DLCO, DLCO%, DLCO/VA and DLCO/VA% were determined significantly lower. High NLR and PET/CT LAP SUVmax values and low DLCO% values are statistically significantly correlated with one-year disease progression. For predicting the progression, for the NLR cut-off value 3.20, the area under the curve was determined as 0.79 (CI 62.2-96.5), sensitivity as 80.0%, specificity as 76.7% and for the PET/CT SUVmax cut-off value 9.5, the area under the curve was determined as 0.71 (CI 46.6-95.9), sensitivity as 70.0%, specificity as 82.1%. We determined that the values observed in routine hematologic examinations such as NLR, RDW and MPV, were high in sarcoidosis cases. In addition, the values of NLR, DLCO% and PET/CT SUVmax might be used in predicting the progression. At the same, once again we showed that the lung parenchyma involvement in PET/CT correlates with many pulmonary function parameters. .
我们旨在揭示中性粒细胞与淋巴细胞比值（NLR）、红细胞分布宽度（RDW）和平均血小板体积（MPV）值与PET/CT结果在疾病进展预测及临床特征方面的相关性。研究纳入了初治的结节病病例，这些病例因纵隔淋巴结肿大接受了PET/CT检查，且活检确诊为结节病。对血液学参数、临床、放射学及PET/CT检查结果进行了评估。本研究纳入了40例结节病患者和40例健康对照。结果显示，结节病组的NLR、RDW、MPV及血沉值在统计学上显著更高。PET/CT显示有实质受累的患者，其用力肺活量（FVC）%、一氧化碳弥散量（DLCO）、DLCO%、DLCO/肺泡通气量（VA）及DLCO/VA%值显著更低。高NLR和PET/CT最大标准化摄取值（LAP SUVmax）以及低DLCO%值与疾病一年进展在统计学上显著相关。为预测疾病进展，对于NLR临界值3.20，曲线下面积为0.79（可信区间62.2 - 96.5），敏感性为80.0%，特异性为76.7%；对于PET/CT SUVmax临界值9.5，曲线下面积为0.71（可信区间46.6 - 95.9），敏感性为70.0%，特异性为82.1%。我们确定在结节病病例中，常规血液学检查中观察到的NLR、RDW和MPV值较高。此外，NLR、DLCO%和PET/CT SUVmax值可能用于预测疾病进展。同时，我们再次表明PET/CT显示的肺实质受累与许多肺功能参数相关。
