Ghasempour Alamdari Masoumeh, Kalami Niusha, Shojaan Horieh, Aminizadeh Sarina, Ghaedi Arshin, Bazrgar Aida, Khanzadeh Shokoufeh
Department of pediatric pulmonology, Tehran university of medical Sciences, Tehran, Iran.
Tuberculosis and lung disease research center. Tabriz University of Medical Sciences. Tabriz, Iran.
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Mar 28;40(1):e2023008. doi: 10.36141/svdld.v40i1.13824.
To outline the observations of studies evaluating the prominence of Neutrophil to Lymphocyte Ratio (NLR) in sarcoidosis.
The search was performed on PubMed, Scopus, and web of science up until November 21, 2021. Eventually, a number of 17 papers were incorporated into this review.
The results of this analysis showed no significant difference of NLR values between sarcoidosis patients and tuberculosis patients (SMD=-0.36, 95% CI= -0.92-0.21). The results showed high heterogeneity (I2=90.83%, p<0.001). So, we used random-effects model. However, NLR can be utilized to identify the radiological severity and staging of pulmonary sarcoidosis due to statistically significant variations. An elevation in NLR values may assist both sarcoidosis diagnosis and lung parenchyma involvement. Also, extra-pulmonary involvement was just more probable to be found in individuals diagnosed with sarcoidosis inhibiting high rates of NLR. High NLR levels were found to be associated with an accelerated rate of progression, revealing that NLR might be used to detect Pulmonary Hypertension (PH) as a complication of sarcoidosis.
In the visualizations of the disease, NLR was revealed to be a beneficial and straightforward fundamental laboratory biomarker connected to disease severity and requirement for therapy.
概述评估中性粒细胞与淋巴细胞比值（NLR）在结节病中突出表现的研究观察结果。
截至2021年11月21日，在PubMed、Scopus和科学网进行检索。最终，17篇论文被纳入本综述。
该分析结果显示，结节病患者与结核病患者的NLR值无显著差异（标准化均数差=-0.36，95%置信区间=-0.92 - 0.21）。结果显示高度异质性（I²=90.83%，p<0.001）。因此，我们使用随机效应模型。然而，由于存在统计学显著差异，NLR可用于识别肺结节病的放射学严重程度和分期。NLR值升高可能有助于结节病的诊断和肺实质受累情况的判断。此外，肺外受累在诊断为结节病且NLR率较高的个体中更有可能被发现。发现高NLR水平与疾病进展加速相关，这表明NLR可用于检测作为结节病并发症的肺动脉高压（PH）。
在该疾病的观察中，NLR被证明是一种与疾病严重程度和治疗需求相关的有益且简单的基础实验室生物标志物。
