Khersonskaia R Ia, Zverkova A S, Fedorovskaia E A, Rogotskaia L T, Zakharenko N I
Vopr Virusol. 1988 Nov-Dec;33(6):690-2.
Clinico-laboratory characteristics of liver lesions occurring in 64 immune donors of blood plasma of 0(1) group are presented. The diseases ran as subclinical, latent, anicteric forms of hepatitis, and only in 5 persons as acute icteric hepatitis. In 50% of the patients there were signs of the disease becoming chronic: long-term increase in the blood serum of the activity of alanine aminotransferase, alkaline phosphatase, variations in bilirubin levels. Certain unresolved and disputable problems of etiological diagnosis of hepatitis in plasma donors, especially in differentiation of autoimmune hepatitis and non-A-non-B hepatitis are discussed.
本文介绍了64名O(1)型免疫血浆捐献者肝脏病变的临床实验室特征。这些疾病以亚临床、潜伏、无黄疸型肝炎形式出现,仅5人表现为急性黄疸型肝炎。50%的患者有疾病转为慢性的迹象:血清中丙氨酸转氨酶、碱性磷酸酶活性长期升高,胆红素水平波动。文中还讨论了血浆捐献者肝炎病因诊断中一些尚未解决和有争议的问题,特别是自身免疫性肝炎和非甲非乙型肝炎的鉴别。