Jabali Shakir Saleem, Saleem Zana Sidiq M, Mohammed Ayad Ahmad, Mahmood Newar M
Urologist, Department of Surgery, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
Nephrologist, Department of Medicine, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
Ann Med Surg (Lond). 2020 May 16;55:107-110. doi: 10.1016/j.amsu.2020.04.038. eCollection 2020 Jul.
Sexual dysfunction is a common problem in patients with chronic kidney disease. Disturbances in sexual function are noticed in early stages of chronic kidney diseases and deteriorate further as renal function declines. This is due to uremic effects, comorbid illness, anemia, hormonal disturbances, autonomic neuropathy, vascular diseases, hyperparathyroidism, hyperprolactinemia, side effects of medications, and psychosocial factors.
This is a cross-sectional study which included 59 male patients who underwent renal transplantation for more than 6 months. The International Index of Erectile Function (IIEF-5) was adopted in our study to record the erectile function.
The mean age was 49.41 years, and the mean number of hemodialysis per month was 5.31. The cause of the chronic kidney disease was diabetes mellitus in 35.59%, glomerulonephritis in 20.34%, and hypertension in 16.95%, other causes were diagnosed in order of decreasing frequency. Most patients developed improvement in the erectile function after transplantation. There was significant correlation with 3 of the elements of the IIFE-5.i.e; penile hardness pre-penetration, Maintaining erection during intercourse, and Difficulty to maintain erection to complete the intercourse (p values 0.015, 0.011, and 0.023) respectively, and the overall improvement after transplantation which showed a p-value of less than 0.031, while there was no significant correlation with Confidence with erection and Satisfaction with intercourse before and after transplantation (p values 0.113 and 0.121) respectively. One of the patients (1.7%) developed severe dysfunction after that.
ED is common sequel of chronic kidney disease. The etiology is multifactorial and may be worsen by advanced age, presence of diabetes mellitus and prolonged duration of hemodialysis. Renal transplantation has a positive impact on sexual function and lead to improvement of erectile dysfunction. Erectile dysfunction that persists after kidney transplantation is usually attributed to multiple preexisting comorbidities.
性功能障碍是慢性肾脏病患者的常见问题。性功能障碍在慢性肾脏病早期即可出现,并随肾功能下降而进一步恶化。这是由于尿毒症影响、合并疾病、贫血、激素紊乱、自主神经病变、血管疾病、甲状旁腺功能亢进、高泌乳素血症、药物副作用以及社会心理因素所致。
这是一项横断面研究,纳入了59例接受肾移植超过6个月的男性患者。本研究采用国际勃起功能指数(IIEF-5)记录勃起功能。
平均年龄为49.41岁,每月平均血液透析次数为5.31次。慢性肾脏病的病因依次为糖尿病占35.59%、肾小球肾炎占20.34%、高血压占16.95%,其他病因按频率递减顺序诊断。大多数患者移植后勃起功能有所改善。IIFE-5的3个要素即插入前阴茎硬度、性交时维持勃起以及性交时维持勃起完成性交困难(p值分别为0.015、0.011和0.023)与移植后总体改善存在显著相关性,移植后总体改善的p值小于0.031,而移植前后勃起信心和性交满意度与之无显著相关性(p值分别为0.113和0.121)。其中1例患者(1.7%)此后出现严重功能障碍。
勃起功能障碍是慢性肾脏病的常见后遗症。其病因是多因素的,可能因高龄、糖尿病的存在以及血液透析时间延长而恶化。肾移植对性功能有积极影响,可改善勃起功能障碍。肾移植后持续存在的勃起功能障碍通常归因于多种既往存在的合并疾病。