Miron Adelina, Nistor Ionut, Morosanu Corneliu, Siriteanu Lucian, Covic Adrian
Department of Urology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, ROU.
Department of Urology and Renal Transplantation, "Dr. C.I. Parhon" Hospital, Iasi, ROU.
Cureus. 2023 Apr 24;15(4):e38088. doi: 10.7759/cureus.38088. eCollection 2023 Apr.
Erectile dysfunction (ED) affects the great majority of people undergoing dialysis and also the majority of patients undergoing kidney transplantation. In this study, we investigated the degree of erectile dysfunction (ED), as well as its prevalence, contributory variables, and overall impact after renal transplant.
Adult male kidney transplant patients were the subject of an observational, non-interventional study that was conducted at a single center. Age, time and type of dialysis before transplantation, comorbidities, factors associated with cardiovascular risk, data on sexual history, physical examination, and laboratory results were among the clinical data we examined. In addition to gathering clinical and demographic characteristics, the International Index of Erectile Function (IIEF) questionnaire was used to evaluate sexual function.
A total of 170 renal transplanted patients between 20 and 70 years old (mean age: 45.40±11.5) were included in this study. All of the patients had immunosuppressive treatment with a calcineurin inhibitor (cyclosporine or tacrolimus) and had a normal glomerular filtration rate (GFR). The prevalence of sexual dysfunction increased with age (42.6% of patients under 40, 47.4% of patients in the 40-60 age group, and 78.9% of patients over 60). Mild, moderate, and severe ED was noted in 33.5%, 20.6%, and 10.6% of cases, respectively, and 51 (30%) patients reported having a normal sexual function. While calcium channel blockers (122 cases) were the most commonly used antihypertensive medication and chronic glomerulosclerosis (55.3%) was the most common cause of chronic kidney disease (CKD) before transplantation, none of these variables appear to have affected the severity of erectile dysfunction. The only medications associated with sexual dysfunction were alpha-blockers and aspirin (75 mg) (p=0.026 and p=0.013, respectively).
Although kidney transplantation has positive impacts on the quality of life, erectile dysfunction is a frequent condition among patients with renal transplants, and it has an increased frequency with age. In our study, it has been observed that only a small percentage of the research group had a normal sexual function, although most of the patients were young, and that alpha-blockers and aspirin (75 mg) are associated with erectile dysfunction.
勃起功能障碍（ED）影响着绝大多数接受透析的患者以及大多数接受肾移植的患者。在本研究中，我们调查了肾移植后勃起功能障碍（ED）的程度、患病率、促成因素以及总体影响。
成年男性肾移植患者是在单一中心进行的一项观察性、非干预性研究的对象。我们检查的临床数据包括年龄、移植前透析的时间和类型、合并症、心血管风险相关因素、性病史数据、体格检查和实验室检查结果。除了收集临床和人口统计学特征外，还使用国际勃起功能指数（IIEF）问卷来评估性功能。
本研究共纳入170例年龄在20至70岁之间（平均年龄：45.40±11.5）的肾移植患者。所有患者均接受了钙调神经磷酸酶抑制剂（环孢素或他克莫司）的免疫抑制治疗，且肾小球滤过率（GFR）正常。性功能障碍的患病率随年龄增长而增加（40岁以下患者中为42.6%，40至60岁年龄组患者中为47.4%，60岁以上患者中为78.9%）。轻度、中度和重度ED分别在33.5%、20.6%和10.6%的病例中被发现，51例（30%）患者报告性功能正常。虽然钙通道阻滞剂（122例）是最常用的抗高血压药物，慢性肾小球硬化症（55.3%）是移植前慢性肾脏病（CKD）最常见的病因，但这些变量似乎均未影响勃起功能障碍的严重程度。与性功能障碍相关的唯一药物是α受体阻滞剂和阿司匹林（75毫克）（分别为p=0.026和p=0.013）。
尽管肾移植对生活质量有积极影响，但勃起功能障碍在肾移植患者中很常见，且随年龄增长发病率增加。在我们的研究中，已观察到尽管大多数患者年轻，但研究组中只有一小部分患者性功能正常，且α受体阻滞剂和阿司匹林（75毫克）与勃起功能障碍有关。
